PENGARUH PEMBERIAN EKSTRAK ETANOL HERBA DAUN SENDOK (Plantago major L.) DAN DAUN SAMBILOTO (Andrographis paniculata Nees) TERHADAP KADAR SGOT DAN SGPT PADA TIKUS YANG DIINDUKSI PARASETAMOL

Rahayuningsih, Diyah (2017) PENGARUH PEMBERIAN EKSTRAK ETANOL HERBA DAUN SENDOK (Plantago major L.) DAN DAUN SAMBILOTO (Andrographis paniculata Nees) TERHADAP KADAR SGOT DAN SGPT PADA TIKUS YANG DIINDUKSI PARASETAMOL. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Herbs of sendok leaf and sambiloto leaf are medicinal plant. Sendok leaf herbs containing aucubin compounds and sambiloto leaf contain andrographolid compounds potentially as hepatoprotectors. This research was conducted to know the dos combination of ethanol extract 70% herbs of sendok leaf and sambiloto leaf which is optimal to reduce levels of SGOT and SGPT in male rats strain wistar that induced paracetamol. This research used 40 rats were divided into 8 groups, each 5 rats that is, group I normal control, group II negative control (CMC 0,5%), group III positive control (curcuma 18 mg / kg BB), group IV given herbs of sendok leaf extract dose 500 mg / kg BB, group V given sambiloto leaf extract 500 mg / kg BB, group VI, VII, VIII were given the extract of the combination of herbs sendok leaf and sambiloto leafwith a dose respectively 125 mg / kg BB : 375 Mg / kg BB, 250 mg / kg BB : 250 mg / kg BB, 3755 mg / kg BB : 125 mg / kg BB. All groups were treated for 13 days. On day 11-13 was given paracetamol expect the normal group. Days 0 and 14 are determined levels of SGOT and SGPT and taken the liver organ to make histology preparations. The data obtained were analyzed by Kruskal Wallis. The results showed that dosage combination of herbs sendok leaf extract and sambiloto leaf extract 125 mg/kg BB : 375 mg/kg BB able to decrease SGOT and SGPT levels, and single doses sambiloto leaf extract 500 mg/kg BB able to inhibit liver cell necrosis in male rats strain wistar that induced paracetamol. Keywords: Plantagomajor L., Andrographis paniculata Nees, paracetamol, SGOT, SGPT

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Plantagomajor L., Andrographis paniculata Nees, paracetamol, SGOT, SGPT
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Rohma Tri Wardani
Date Deposited:	25 Feb 2019 03:06
Last Modified:	25 Feb 2019 03:06
URI:	http://repo.setiabudi.ac.id/id/eprint/1000

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