UJI AKTIVITAS SENYAWA ANALOG 3’,4’-DIKLOROKALKON PADA BAKTERI Staphylococcus aureus ATCC 25923

Anjaeni, Githa Fahma Nurul Kusuma (2017) UJI AKTIVITAS SENYAWA ANALOG 3’,4’-DIKLOROKALKON PADA BAKTERI Staphylococcus aureus ATCC 25923. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Chalcones are considered as the precursors of flavonoids which consist of two aromatic rings linked a three-carbon α,β-unsaturated carbonyl sytem. Chalcones and is derivates have been rreprted to prossess various biological activities such as antibacterial, anticancer, antifungal, anti-inflammatory and antioxidant. The aim of this study activity compound 3’,4’-diclorochalcone an aktivity bacterial Staphylococcus aureus ATCC 25923. The compound of 3’,4’-diclorochalcone were obtained from the Laboratory of Syntesis Organic Setia Budi University. The test activity used dilution method to know cocncentration Kill Minimum of the chalcone derivatives compound. Dilution method by 10 tube dilution, which from a dilution series with concentration of 2500 µg/ml, 1250 µg/ml, 625 µg/ml, 312,5 µg/ml 156,25 µg/ml, 78,125 µg/ml, 39,062 µg/ml, 19,531 µg/ml, then inoculated on defferential medium VJA (Vogel Johnson Agar). Based on electronic parameters (Cβ enon group), lipophilicity (log P) and steric (index winner). Qualitative analysis of structural relationship and antibacterial anktivity in gram positiv was performed. The result of the experimen showed that compound 3-(3-indolil)-1-(3,4diklorfenil)prop-2-en-1-on had the activity at 2500 µg/ml concentration, while compound 1-(3,4-diklorofenil)-3-(2-furanil)prop-2-en-1-on showed no activity antibacterial at concentration 5000 µg/ml had greater inhibitor potency than compound 1-(3,4-diklorofenil)-3-(2-furanil)prop-2-en-1-on at bacterial Staphylococcus aureus ATCC 25923. Key words : Chalcones are considered as the precursors of flavonoids which consist of two aromatic rings linked a three-carbon α,β-unsaturated carbonyl sytem. Chalcones and is derivates have been rreprted to prossess various biological activities such as antibacterial, anticancer, antifungal, anti-inflammatory and antioxidant. The aim of this study activity compound 3’,4’-diclorochalcone an aktivity bacterial Staphylococcus aureus ATCC 25923. The compound of 3’,4’-diclorochalcone were obtained from the Laboratory of Syntesis Organic Setia Budi University. The test activity used dilution method to know cocncentration Kill Minimum of the chalcone derivatives compound. Dilution method by 10 tube dilution, which from a dilution series with concentration of 2500 µg/ml, 1250 µg/ml, 625 µg/ml, 312,5 µg/ml 156,25 µg/ml, 78,125 µg/ml, 39,062 µg/ml, 19,531 µg/ml, then inoculated on defferential medium VJA (Vogel Johnson Agar). Based on electronic parameters (Cβ enon group), lipophilicity (log P) and steric (index winner). Qualitative analysis of structural relationship and antibacterial anktivity in gram positiv was performed. The result of the experimen showed that compound 3-(3-indolil)-1-(3,4diklorfenil)prop-2-en-1-on had the activity at 2500 µg/ml concentration, while compound 1-(3,4-diklorofenil)-3-(2-furanil)prop-2-en-1-on showed no activity antibacterial at concentration 5000 µg/ml had greater inhibitor potency than compound 1-(3,4-diklorofenil)-3-(2-furanil)prop-2-en-1-on at bacterial Staphylococcus aureus ATCC 25923. Key words : 3’,4’-diclorochalcone, Staphylococcus aureus ATCC 25923, dilusi

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	3’,4’-diclorochalcone, Staphylococcus aureus ATCC 25923, dilusi
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Rohma Tri Wardani
Date Deposited:	25 Feb 2019 03:17
Last Modified:	25 Feb 2019 03:17
URI:	http://repo.setiabudi.ac.id/id/eprint/1062

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