AKTIVITAS ANTIBAKTERI FRAKSI n-HEKSANA, ETIL ASETAT dan AIR DARI EKSTRAK METANOL DAUN KENIKIR (Cosmos caudatus Kunth) TERHADAP Bacillus subtilis ATCC 6633

Faudiyah, Hanim (2017) AKTIVITAS ANTIBAKTERI FRAKSI n-HEKSANA, ETIL ASETAT dan AIR DARI EKSTRAK METANOL DAUN KENIKIR (Cosmos caudatus Kunth) TERHADAP Bacillus subtilis ATCC 6633. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Leaf kenikir (Cosmos Caudatus K) contains flavonoids, saponins, essential oils and polyphenols that are suspected of having antibacterial activity. Bacillus subtilis ATCC 6633 can cause diseases of immune function impaired, such as meningitis, endocarditis, endophthalmitis, food poisoning and diarrhea. The purpose of this research is to know the antibacterial activity of fraction of nhexane, ethyl acetate and water from methanol leaf extract (Cosmos Caudatus K) to Bacillus subtilis ATCC 6633. Leaf kenikir powder was extracted using maseration method with methanol solvent then fractionated using n-hexane, ethyl acetate, and water solvent. Test of antibacterial activity against B. subtilis ATCC 6633 using diffusion and dilution method. The concentration of extract and fraction used for the diffusion method was 50%, 25%, and 12.5%. The concentrations used for the dilution method were 50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, 0.78%, 0.39% and 0.195%. Based on the diffusion method, the inhibitory was obtained from concentration of 50% methanol extract 15 mm, 16 mm n-hexane fraction, 22 mm ethyl acetate fraction and 16 mm water fraction. KBM from ethyl acetate fraction to B. subtilis ATCC 6633 with dilution method was 6.25%. The ethyl acetate fraction has the greatest antibacterial activity inhibiting B. subtilis ATCC 6633. Keywords: Cosmos Caudatus K., fractionation, B. subtilis ATCC 6633, antibacterial.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Cosmos Caudatus K., fractionation, B. subtilis ATCC 6633, antibacterial.
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Rohma Tri Wardani
Date Deposited:	25 Feb 2019 03:18
Last Modified:	25 Feb 2019 03:18
URI:	http://repo.setiabudi.ac.id/id/eprint/1070

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