UJI AKTIVITAS ANALGESIK EKSTRAK ETANOL DAUN SINTRONG (Crassocephalum crepidioides (Benth.) S. Moore) DENGAN METODE RANDALL SELITTO DAN WRITHING TEST

Dewi, Resawati Permata (2017) UJI AKTIVITAS ANALGESIK EKSTRAK ETANOL DAUN SINTRONG (Crassocephalum crepidioides (Benth.) S. Moore) DENGAN METODE RANDALL SELITTO DAN WRITHING TEST. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Pain is defined as a sensory and emotional experience that not associated with tissue damage. The aims of the research were to determine analgesic effect of Crassochepalum crepidioides (Benth.) S. Moore Leaf ethanolic extract and to determine the dose of Crassochepalum crepidioides (Benth.) S. Moore Leaf the highest analgesic activity with Randall Selitto and writhing test method. Randall Selitto and writhing test methodhave been used extensively for the development of non-steroidal antiinflammatory drugs. Crassochepalum crepidioides (Benth.) S. Moore Leaf was extracted by maceration method with ethanol 96%. 30 male white rats strain wistar divided in 5 groups, positive control mefenamic acid 9 mg/ 200 g BB, negative control CMC Na, Crassochepalum crepidioides (Benth.) S. Moore Leaf ethanolic extract doses 5 mg/ 200 g BB, 10 mg/ 200 g BB and 20 mg/ 200 g BB. Data were analyzed using ANOVA and LSD test was done to know the difference between the treatmeant groups. The result of the research showed that ethanolic extract doses 5 mg/ 200 g BB, 10 mg/ 200 g BB and 20 mg/ 200 g BB compare with positive control was indicated that ethanolic extract doses 20 mg/ 200 g BB showed the highest analgesic activity. Steroid an flavonoid compounds contained in Crassochepalum crepidioides (Benth.) S. Moore Leaf are thought to have an analgesic effect. Key words : analgesic, Randall Selitto, writhing test, daun sintrong

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	analgesic, Randall Selitto, writhing test, daun sintrong
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Herera Gadys USB
Date Deposited:	25 Feb 2019 03:18
Last Modified:	25 Feb 2019 03:18
URI:	http://repo.setiabudi.ac.id/id/eprint/1076

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