Oktastika, Hesty Riza (2017) UJI TOKSISITAS AKUT KOMBINASI EKSTRAK ETANOL RIMPANG KUNYIT (Curcuma domesticaVal.) dan JAHE (Zingiber officinale Rosc.) PADA TIKUS PUTIH BETINA GALUR WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Turmeric rhizome (Curcuma domestica Val.) And ginger (Zingiber officinale Rosc.) are traditional plants that widely available in nature. The plants are used as traditional medicines one of them as anti-inflammatory, but there is no research to examine the safety standard of turmeric rhizome and ginger extract. This study was aimed to examine the effects of acute toxicity on white female rat. Combination of turmeric and ginger rhizome was soclethlet with ethanol 70% until obtained thick extract. Acute toxicity test was performed with fixed dosed method using female rat as much as 30 animals divided into 6 groups, namely negative control, dose 5 mg/kgBW, 50 mg/kgBW, 300 mg/kgBW, 2000 mg/kgBW, and 5000 mg/KgBW. The study was conducted for 24 hours to 14 days, index of rat organ weight was statistically tested with one way ANAVA and continued Post-Hoc. The results showed that combination ethanolextracts of turmeric and ginger rhizome to dose of 5000 mg/kgBW is result in the death of test animals and no significant toxic effects, so it can be stated safe, may affect the autonomic nervous changes and neurological changes, and may affect the organ weight, and organ macroscopic. Thus LD50 ethanol extract of turmeric and ginger rhizomes in rat greater is 707,945mg/KgBW with letalitas level is slightly toxic. Keywords: Acute toxicity, turmeric rhizome, and ginger rhizome
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Acute toxicity, turmeric rhizome, and ginger rhizome |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Rohma Tri Wardani |
| Date Deposited: | 25 Feb 2019 03:19 |
| Last Modified: | 25 Feb 2019 03:19 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/1081 |
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