UJI AKTIVITAS FRAKSI-FRAKSI DARI EKSTRAK ETANOL DAUN JAMBLANG (Syzygium cumini (L.) Skeels) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL DAN LEMAK ABDOMINAL PADA TIKUS PUTIH JANTAN

Karmila, Karmila (2017) UJI AKTIVITAS FRAKSI-FRAKSI DARI EKSTRAK ETANOL DAUN JAMBLANG (Syzygium cumini (L.) Skeels) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL DAN LEMAK ABDOMINAL PADA TIKUS PUTIH JANTAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Jamblang leaves extract on previous research has activity to reduce total cholesterol level in blood and abdominal fat in mice given a high-fat diet. The purpose of this research was to determine the activity fractions from ethanol extract of jamblang leaves (Syzygium cumini (L.) Skeels) to reduce blood total cholesterol level and abdominal fat male rats hypercholesterolemia. White male rats were divided into 8 groups, normal control, negative control (solution of CMC 0,5%), positive control (simvastatin), extract (400 mg/200 g BW), ethyl acetate fraction dose of 4,84 mg/200 g BW, ethyl acetate fraction dose of 9,68 mg/200 g BW, ethyl acetate fraction dose of 19,36 mg/200 g BW and water fraction dose of 60,72 mg/200 g BW. The rats adapted for 7 days and was given a high-fat diet for 14 days. The preparation test were given for 14 days. Measurement of total cholesterol level using CHOD-PAP method and the data analyzed with Oneway Anova statistics at 95% significant level. The results of research showed that fractions from ethanol extract of jamblang leaves (Syzygium cumini (L.) Skeels) have anticholesterol activity. Reduce exract dose of 400 mg/200 g as 44,65%, ethyl acetate fraction ½ (4,84 mg/200 g BB) as 19,86%, ethyl acetate fraction 1 (9,68 mg/200 g BW) as 29,03%, ethyl acetate fraction 2 (19,36 mg/200 g BW) as 43,76% and water fraction (60,72 mg/200 g BW) as 13,94%. Exract dose of 400 mg/200 g and etyl acetate fraction at dose of 19,36 mg/200 g BW most effective to lower total cholesterol level white male rats, but for lower abdominal fat all groups didn’t show significant. Keywords: Jamblang leaves (Syzygium cumini (L.) Skeels), total cholesterol, abdominal fat

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Jamblang leaves (Syzygium cumini (L.) Skeels), total cholesterol, abdominal fat
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Rohma Tri Wardani
Date Deposited:	25 Feb 2019 03:22
Last Modified:	25 Feb 2019 03:22
URI:	http://repo.setiabudi.ac.id/id/eprint/1122

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