UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN

Muharomah, Siti Imro’atul (2018) UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Red betel leaf plants contain flavonoids as a decrease in blood glucose and prevent tissue damage due to oxidative stress. The aim of this research is to know the extract of red betel leaf ethanol (Piper crocatum) to have antidiabetic activity to decrease blood glucose level and to improve pancreatic histopathology in alloxan-induced rats. This study used 6 groups of male wistar rats. Group I (normal control); group II (negative control); group III (positive control); group IV (red betel leaf extract dose 100 mg / kg bb); group V (red betel leaf extract dose 200 mg / kg bb) and group VI (red betel leaf extract dose 400 mg / kg bb). After 21 days of treatment of decreased blood glucose level and pancreatic histopathology on βcell Langerhans island mice data were analyzed by one way anova method (p <0,05) followed by tukey test. The results of this study indicate that red betel leaf extract has activity to lower blood glucose levels and improve histopathology of pancreatic organ of mice. The most effective dose of red betel leaf extract dose 100 mg / kg bb where there is a decrease in blood glucose levels proportional to glibenclamide as a positive control. Keywords: Red betel leaf (Piper crocatum), Blood glucose, alloxan, histopathology of pancreas.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Red betel leaf (Piper crocatum), Blood glucose, alloxan, histopathology of pancreas.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	25 Feb 2019 03:33
Last Modified:	25 Feb 2019 03:33
URI:	http://repo.setiabudi.ac.id/id/eprint/1179

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