Ubanayo, Kristian (2017) PENGARUH EKSTRAK AKAR PASAK BUMI (Eurycoma longifolia) SEBAGAI NEFROPROTEKTOR PADA TIKUS YANG DIINDUKSI GENTAMISIN. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Gentamicin is an antibiotic that is most often used to treat bacterial infections. Overused of gentamicin, causing gentamicin accumulates in the kidneys will damage the kidneys. One of the plants that can be used to protect the kidneys from damage caused by gentamicin is Pasak Bumi root (Eurycoma longifolia). The purpose of this study was to examine administration of Pasak Bumi root extract can give nephroprotector effect in rat gentamicin-induced through parametera of urea and creatinine in blood. Extraction of Pasak Bumi root was done in PETO (center of medicinal plant extraction) Tawangmangu. The experiment using 30 experimental animals were divided into 6 groups. Normal control group, negative control group, sick control group, extract of pasak bumi root dose of 100 mg / 200 g BW, extract of pasak bumi root dose of 150 mg / 200 g BW and extract of pasak bumi root dose of 200 mg / 200 g BW. Blood sampling was conducted twice, on day 0 (before gentamicin-induced) and day 15 and then measured the levels of urea and creatinine in the blood. Data were statistically tested using SPSS 17. The results showed that the extract of Pasak Bumi roots could give nephroprotector effect in rat gentamicin-induced through parameters of urea and creatinine in the blood. Dose of Pasak Bumi roots extract that shows the most effective nephroprotector effect was Pasak Bumi root extract dose of 100 mg / 200 g BW. Thus, Increase of dose was not associated with an increase nephroprotector effect in rat gentamicin-induced through parameters of urea and creatinine in the blood. Keywords: Pasak Bumi root, urea and creatinine, nephroprotector
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Pasak Bumi root, urea and creatinine, nephroprotector |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Rohma Tri Wardani |
| Date Deposited: | 25 Feb 2019 03:39 |
| Last Modified: | 25 Feb 2019 03:39 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/1213 |
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