Kartini, Lilik (2017) PENGARUH PEMBERIAN KOMBINASI EKSTRAK ETANOL DAUN SALAM (Eugenia polyantha W.) DAN DAUN MANGGA ARUMANIS (Mangifera indica L.) TERHADAP KADAR MALONALDEHIDA (MDA) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Oxidative stress that occurs in uncontrolled diabetes could lead to increased lipid peroxidation produce a final product that is MDA. Antioxidants were used to suppress oxidative stress. This aim of this study was determine the effect and effective dose of the combination of salam and mango leaves against MDA level in male rats induced by alloxan. White male rats were divided into eight groups: three groups of controls (normal, negative, positive), two groups are single dose (salam leaves 91,7 mg/Kg BW and mango leaves 147 mg/Kg BW), and three groups of variations in dose combination 25% : 75% (22,925 mg/Kg BW : 110,25 mg/Kg BW), 75% : 25% (68,775 mg/Kg BW : 36,75 mg/Kg BW), and 50% : 50% (45,85 mg/Kg BW : 73,5 mg/ Kg BW)Rats were treated for 14 days orally and MDA level was measured by spectrophotometer λ 532 nm. MDA levels were statistically analyzed by ANOVA. The results of research showed that dose combination of salam and mango leaves 75% : 25% (68,775 mg/Kg BW : 36,75 mg/Kg BW) have influence decreased levels of liver MDA of 2.452 ± 0.118 nmol/g being the most effective dose were compared with the positive control group. Keywords: salam (Eugenia polyantha W.), mango (Mangifera indica L.), alloxan, diabetes mellitus, level malondialdehide (MDA)
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | salam (Eugenia polyantha W.), mango (Mangifera indica L.), alloxan, diabetes mellitus, level malondialdehide (MDA) |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Rohma Tri Wardani |
| Date Deposited: | 25 Feb 2019 03:39 |
| Last Modified: | 25 Feb 2019 03:39 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/1222 |
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