AKTIVITAS ANTIPARKINSON EKSTRAK GAMBIR (Uncaria gambir Roxb.) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR Sprague Dawley YANG DIINDUKSI HALOPERIDOL

Nofitasari, Lutfi (2017) AKTIVITAS ANTIPARKINSON EKSTRAK GAMBIR (Uncaria gambir Roxb.) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR Sprague Dawley YANG DIINDUKSI HALOPERIDOL. Skripsi thesis, Universitas Setia Budi Surakarta.

	Text INTISARI.pdf Download (90kB)
	Text SKRIPSI.pdf Download (3MB)

Abstract

Parkinson disease is a disease that occurs due to damage to dopaminergic nerve cells in the brain which resulted in decreased dopamine production. Gambir is a dried extract made from the leaves of Uncaria gambir Roxb plant. Gambir contains no less than 90% catechin flavonoids that can penetrate the blood brain barrier and can prevent oxidative stress, alkaloid and terpenoids. This study aims to determine the activity of gambir extract that can reduce the symptoms of Parkinson's in the male rats Sprague dawley induced haloperidol. Test animals of 35 rats divided into 7 groups. Group I (healthy control) was given aquadest orally, group II (negative control) was given a 0.5% CMC-Na solution, group III (positive control I) was given levodopa 27 mg / kgbw po, group IV (positive control II ) Were given vitamin E 180 IU / kgbw po. Groups V, VI, and VII were given a dose of 70 consecutive gambir extracts; 140; 280 mg / kgbw. The whole group induced haloperidol 2 mg / kgbw i.p at the 45th minute after treatment except in the healthy group. Then the group was tested with a catalepsy bar test, recorded the latency time expressed in the score and rota test rod, recorded time latency in seconds on days 0, 4, 7, 11, and 14. The result of this research is catalepsy bar test method at gambir extract dose 70; 140; 280 mg / kgbw showed a catalytic decrease activity of 22,53; 52,50; 57,12%. While the results with rota rod test method showed the increase activity in the latency time of 27,69; 35,75; 39,61%. The dose of gambir extract effective in reducing Parkinson's symptoms is 140 mg / kgbw. Keywords: antiparkinson, gambier extract, catalepsy bar test, rota rod test.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	antiparkinson, gambier extract, catalepsy bar test, rota rod test
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Rohma Tri Wardani
Date Deposited:	25 Feb 2019 03:40
Last Modified:	25 Feb 2019 03:40
URI:	http://repo.setiabudi.ac.id/id/eprint/1233

Actions (login required)

View Item