FORMULASI GEL HAND SANITIZER EKSTRAK DAUN UNGU (Graphtophyllum pictum (L.) Griff) DENGAN VARIASI BASIS CARBOPOL 940 DAN CMC-Na SERTA UJI AKTIVITAS TERHADAP BAKTERI Staphylococcus aureus ATCC 25923

Syaiban, Syaiban (2017) FORMULASI GEL HAND SANITIZER EKSTRAK DAUN UNGU (Graphtophyllum pictum (L.) Griff) DENGAN VARIASI BASIS CARBOPOL 940 DAN CMC-Na SERTA UJI AKTIVITAS TERHADAP BAKTERI Staphylococcus aureus ATCC 25923. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Purple leaves have properties as constipation drugs, urinary drugs, menstruation drugs, drugs ulcers, and hemorrhoids. The purple leaves (Graphtophyllum pictum (L.) Griff) contain flavonoids, saponins, tannins, alkaloids, steroids. Purple leaf extract is known to have antibacterial activity against Staphylococcus aureus. The purpose of this study was to determine the effect of gelling agent concentration variation of Carbopol 940 and CMC-Na in the preparation of gel preparation of purple leaf soil sanitizer and activity test on ATCC Staphylococcus aureus 25923. Purple leaf were extracted with a maceration method with 96% ethanol. Then purple leaf extract was prepared gel preparation using formula 5, formula I, formula II, formula III, formula IV, and formula V with concentration of carbopol 940 and CMC-Na respectively 1: 0; 0.75: 0.25; 0.5: 0.5; 0.25: 0.75; And 0: 1. Gel preparation of hand sanitizer purple leaf extract tested the physical properties and stability of gel for 21 days and tested its antibacterial activity by diffusion method. The data obtained were analyzed using One Sampel Kolmogorov Smirnov and One Way Anova on SPSS program. The gel stability test results obtained from I - V formula yielded gel preparation from purple leaf extract which was stable for 21 days storage and had antibacterial activity. The gel preparation of the IV formula had the best physical and stability properties for 21 days of storage as well as the 9.67 mm antibacterial inhibitory zone of Staphylococcus aureus. Keywords : Purple leaves (Graphtophyllum pictum (L.) Griff), gel, carbopol 940, CMC-Na, stability, antibactery, Staphylococcus aureus.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Purple leaves (Graphtophyllum pictum (L.) Griff), gel, carbopol 940, CMC-Na, stability, antibactery, Staphylococcus aureus.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Herera Gadys USB
Date Deposited:	25 Feb 2019 03:41
Last Modified:	25 Feb 2019 03:41
URI:	http://repo.setiabudi.ac.id/id/eprint/1245

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