FORMULASI DAN KARAKTERISASI SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM MELOKSIKAM DENGAN VARIASI MINYAK ZAITUN DAN VCO

Kurniawan, Yesika Dwiastuti (2017) FORMULASI DAN KARAKTERISASI SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM MELOKSIKAM DENGAN VARIASI MINYAK ZAITUN DAN VCO. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Meloxicam is one of non-steroidal anti-inflammatory (NSAID) enolate acid derivative which acts as an inhibitor of the biosynthesis of prostaglandins, the enzyme cyclooxygenase 2 (COX-2). Characteristics of meloxicam is included indrug classification class biopharmaceuticalsystem (BCS) II is the drug has a low solubility and high permeability. One strategy to overcome the problems of low solubility that is self-nanoemulsifying drug delivery system (SNEDDS). SNEDDS is a drug consisting of a mixture of isotropic between drugs, oils and surfactants and if required one or more cosurfactants. This study aims to determine the type of oil that can provide the best drug loading and the optimum formula of the oil phase, surfactant and cosurfactant with characterization tests include: emulsification time, drug loading and percent trasnsmittance. The determination of the optimum formula SNEDDS meloxicam viewed using Simplex Lattice Design method with Design Expert 7.5.1. The results showed that the VCO is easier to dissolve meloxicam than olive oil. Optimization results obtained optimum formula VCO is equal to 2.67 mL, Tween 80 of 5.67 mL and 1.67 mL of PEG 400 with its characterization emulsification time of 14,60 0,111 seconds, a drug loading of 1,60 1,378 ppm, and the percent transmittance 29,10 0,361%. Keywords: meloxicam, SNEDDS, VCO, Tween 80, PEG 400.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: meloxicam, SNEDDS, VCO, Tween 80, PEG 400.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 25 Feb 2019 03:43
Last Modified: 25 Feb 2019 03:43
URI: http://repo.setiabudi.ac.id/id/eprint/1285

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