UJI TOKSISITAS SUBKRONIS SINGKAT EKSTRAK ETANOL BIJI MAHONI (Swietenia mahagoni Jacq.) TERHADAP BUN, KREATININ, DAN HISTOPATOLOGI GINJAL PADA TIKUS PUTIH GALUR WISTAR

RAHMAWATI, Afifah Mifta Aulia (2016) UJI TOKSISITAS SUBKRONIS SINGKAT EKSTRAK ETANOL BIJI MAHONI (Swietenia mahagoni Jacq.) TERHADAP BUN, KREATININ, DAN HISTOPATOLOGI GINJAL PADA TIKUS PUTIH GALUR WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Mahogany seeds are one of the traditional medicinal plants that can be used as a treatment of peptic ulcer. The purpose of this study is to determine the effects of short sub-chronic toxicity of ethanol extract mahogany seeds (EEBM) on body weight, toxic symptoms and clinical symptoms, the percentage mortality, levels of Blood Urea Nitrogen (BUN), creatinine levels, and kidney histopathology male and female wistar strain white rats. Making EEBM by maceration using 95% ethanol. This study used 50 rats consisting of males and females in the 5 groups administered orally for 28 days. The control group was given CMC Na 0,5%, EEBM dose group were given a dose of 200; 400; 800 mg / kg, and a group of satellites. Carried out observations of body weight, toxic symptoms and clinical symptoms, the percentage mortality, levels of BUN, creatinine, and kidney histopathology of rats. The use of EEBM dose of 200; 400; and 800 mg/kgBB given to the rats did not cause a toxic effect on a short subchronic toxicity test. It can be seen from the observations result of EEBM did not affect the body weight; toxic symptoms and clinical symptoms and did not cause the rats death, did not affect the levels of BUN; creatinine levels; and kidney histopathology male and female wistar strain white rats. Keyword: EEBM, short subchronic, BUN, creatinine, histopathology

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: EEBM, short subchronic, BUN, creatinine, histopathology
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 26 Sep 2019 07:49
Last Modified: 26 Sep 2019 07:49
URI: http://repo.setiabudi.ac.id/id/eprint/1302

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