UJI TOKSISITAS SUBKRONIK EKSTRAK ETANOL BUAH PINANG(Areca catechu L.) TERHADAP KADAR KREATININ DAN BUN (Blood Ureum Nitrogen) TIKUS PUTIH GALUR WISTAR

NIFU, Antoneta Diana (2016) UJI TOKSISITAS SUBKRONIK EKSTRAK ETANOL BUAH PINANG(Areca catechu L.) TERHADAP KADAR KREATININ DAN BUN (Blood Ureum Nitrogen) TIKUS PUTIH GALUR WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Areca (Areca catechu L.) contains alkaloid as arecoline, arecolidine, arecaine, guvacoline, guvasine, isoguvasine, condensed tannin, hydrolyzed tannin, flavaniline, phenolic, gallic acid, latex, lignin, evaporated and non-evaporated oil, and salt. This study was aimed to find out the effect of subchronic toxicity of areca ethanol extract on the level change of Blood Ureum Nitrogen (BUN) and Plasma Creatinine in the male and female white mouse Wistar strain. The extraction method used was maceration with ethanol 70%. This study used 60 male and female white mice which divided into 6 groups. Dose I (CMC 0.5%), dose II (34,2mg/kg BW), dose III (1500mg/kg BW), dose IV (areca extract 2000mg/ kg BW), satellite 6.84mg/kg BW, and satellite 2000mg/kg BW for one month. Data was obtained at the beginning of t before and at the end of the month, satellite was obtained 14 days after day-29 of data collection. The data of BUN and Plasma Creatinine examination result was analyzed using Shapiro-Wilkand One Way Anova. The result of the study showed that oral administration of areca extract for one month lead to a toxic effect on kidneys in male and female white mice, observed by the result of the increased level of BUN and Plasma Creatinine above normal at dose 2000mg/kg BW. Keywords: Areca catechu L., subchronic toxicity, level of BUN and Plasma creatinine.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Areca catechu L., subchronic toxicity, level of BUN and Plasma creatinine.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	26 Sep 2019 08:12
Last Modified:	26 Sep 2019 08:12
URI:	http://repo.setiabudi.ac.id/id/eprint/1313

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