UJI TOKSISITAS SUBKRONIS SINGKAT EKSTRAK METANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) TERHADAP KADAR SGOT, SGPT DAN HISTOPATOLOGI HATI PADA TIKUS PUTIH (Rattus norvegicus)

AMRILLAH, Fikri (2016) UJI TOKSISITAS SUBKRONIS SINGKAT EKSTRAK METANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) TERHADAP KADAR SGOT, SGPT DAN HISTOPATOLOGI HATI PADA TIKUS PUTIH (Rattus norvegicus). Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Red betel leaves (Piper crocatum Ruiz & Pav) contains sereval compounds are efficacious in the treatment of such flavonoids, tanins, and saponins. This study aimed to examine the the effect of subchronic toxicity and determine subchronic toxicity of methanol extract red betel leaves to changes in SGPT, SGOT and histopathologycal of the liver white rats. The extraction method used was macerated with methanol. The study used test animals wistar strain male and female rats by 50 tails are devide into 5 groups: control negative (CMC 4%), the first dose (200 mg/bw), the second dose (400 mg/bw), the third dose (800 mg/bw) for 1 month and the satellite group plus 14 day. Data were obtained every week and histopathologycal picture of the liver at the end of last week. Data SGPT and SGOT test result were analyzed using Paired t-test and Anova Two Way, for histopathologycal outcome ware analyzed using Anova Two Way. The result showed that the methanol extract of red betel leaves orally did not give a toxic effect on the liver white male and female rats were seen from the result of SGPT and SGOT levels, and histopathologycal parameters were observed. Keyword: red betel leaves, toxicity, SGPT/SGOT levels and histopathologycal

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: red betel leaves, toxicity, SGPT/SGOT levels and histopathologycal
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 30 Sep 2019 04:11
Last Modified: 30 Sep 2019 04:11
URI: http://repo.setiabudi.ac.id/id/eprint/1369

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