UJI SITOTOKSIK EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA SEL KANKER KOLON WiDr

TRIPUTRA, Jimmy (2016) UJI SITOTOKSIK EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA SEL KANKER KOLON WiDr. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Colon cancer is a second ranks on leading causes of death among other types of cancer in developing countries. The research to obtain anti cancer drugs from natural increase. Red betel (Piper crocatum Ruiz & Pav) is one of the medicinal plants that are empirically used by people as a traditional drug for diabetes mellitus, gout, hypertension, cholesterol and breast cancer. The aim of this research is to determine the cytotoxic activity and also the selectivity of ethanol extract of red betel leaf against WiDr cells. This research contains the extraction of red betel leaf using remaceration method with 70% ethanol solvent. The investigation of cytotoxic activity of ethanol extract of red betel leaf was done by using [3-(4,5-dimetiltiazol-2-il)-2,5difenil tetrazolium bromida] (MTT) method with concentration series of (1000; 500; 250; 125; 62,5; 31,2; 15,6; 7,8) µg/ml and IC50 values calculated using linear regretion. The selectivity of cytotoxic activity was known by using selectivity index equation, which was IC50 of vero cells proportionate with IC50 of WiDr cells. The result of the cytotoxic activity assay of ethanol extract of red betel leaf using MTT method did not show a potent cytotoxic activity with IC50 value of 520,826 µg/mL, while selectivity index is gotten value of 2,31. Keywords: red betel leaf, WiDr cells, cytotoxic, selectivity index

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: red betel leaf, WiDr cells, cytotoxic, selectivity index
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:14
Last Modified: 01 Oct 2019 03:14
URI: http://repo.setiabudi.ac.id/id/eprint/1392

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