SAPUTRI, Alip Desi Suyono (2016) OPTIMASI FORMULA KRIM MINYAK ATSIRI DAUN ROSEMARY (Rosmarinus officinalis L) MENGGUNAKAN EMULGATOR TWEEN 80 DAN SPAN 80 SEBAGAI ANTIBAKTERI DENGAN METODE DESAIN FAKTORIAL. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
The leaves of rosemary (Rosemarinus Officinale l.) is a traditional medicinal ingredients with essential oils that are effective as antibacterial. The use of essential oils directly assessed less practical, so it was made a cream preparations. Thes study was aims obtained to get the optimum formula cream of essential oils of rosemary leaves with a proportion of emulgator tween 80 and span 80 based on factorial design method and the optimum formula of antibacterial activity against Staphylococcus aureus ATCC 25923. Isolation of rosemary leaf essential oil was done using water distillation method. The Cream was made in four formulas based on factorial design method. The obtained cream were tested its four physical properties, i.e organoleptic, viscocity, pH, spread ability, adhesivity, pH value, and antibacterial activity with difution method. The optimum obtained formula using the formula Design Expert version 8.0.6.1 created and tested his physical properties. predicted was compared with the experimentation result using T-test. The antibacterial activity of the optimum formula was tested by diffusion method. The results of this research provide the Optimum formula of Rosemary leaf volatile oil cream was obtained from the proportion of Tween 80 : Span 80 0,94 : 8,13. The response indicated that it did not have significant differentiation between predict percentage and the experimentation result. Antibacterial activity of optimum formula resulted 18,7 mm inhibition zone. Keywords: antibacterial, leaf essential oil of rosemary (Rosemarinus Offinale L.), factorial design, cream, Staphylococcus aureus ATCC 25923.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | antibacterial, leaf essential oil of rosemary (Rosemarinus Offinale L.), factorial design, cream, Staphylococcus aureus ATCC 25923. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 01 Oct 2019 03:33 |
| Last Modified: | 01 Oct 2019 03:33 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/1526 |
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