UJI AKTIVITAS ANTIOKSIDAN SEDIAAN KRIM EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) TERHADAP RADIKAL BEBAS DPPH (1,1 Difenil-2-pikrilhidrazil)

KUNCORO, Dimas Tutug Setyo (2015) UJI AKTIVITAS ANTIOKSIDAN SEDIAAN KRIM EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) TERHADAP RADIKAL BEBAS DPPH (1,1 Difenil-2-pikrilhidrazil). Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Antioxidant is an important compound that has been used to maintain of health and protect against of negative effects from free radical. Flavonoid from Annona muricata L. leaf can be used as antioxidant. The aim this research is to know variation concentration effect of turmeric ethanolic extract in cream formulation to the physical stability and antioxidant activity.. The Annona Muricata L leaf was extracted by maceration method using ethanol 70% (b/v). Cream was prepared using 5 formulations i.e. Formula 1 (F1), Formula 2 (F2), and Formula 3 (F3) containing of 6, 9, and 12% (b/v) of Annona muricata L. leaf ethanolic extract, respectively. Formula 4 (F4) was consisting of rutin 1% as positive control, and Formula 5 (F5) as negative control. The antioxidant activity testing was conducted using DPPH method. The homogeneity, spread ability, adhesion, viscosity, pH, and type of cream were conducted as physical inspections of cream. The results showed that ethanol extract of Annona Muricata L leaf cream The antioxidant activity of Annona Muricata L. with IC50 of 368.97 ppm and can be made preparations cream. The Result from antioxidant activity shows IC50 of formula 1, 2, and 3 straight up is 616,60 ppm, 575,43 ppm, and 407,38 ppm respectively. ethanolic extract showed that significant difference during 21 days storage. Keywords: ethanolic extract of Annona Muricata L., cream, physical stability test, test the antioxidant activity

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: ethanolic extract of Annona Muricata L., cream, physical stability test, test the antioxidant activity
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:34
Last Modified: 01 Oct 2019 03:34
URI: http://repo.setiabudi.ac.id/id/eprint/1540

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