FORMULASI SEDIAAN GEL HAND SANITIZER MINYAK ATSIRI DAUN ROSEMARY (Rosmarinus officinalis L.) DAN AKTIVITASNYA TERHADAP Staphylococcus aureus ATCC 25923

WIBOWO, Guruh Arief (2015) FORMULASI SEDIAAN GEL HAND SANITIZER MINYAK ATSIRI DAUN ROSEMARY (Rosmarinus officinalis L.) DAN AKTIVITASNYA TERHADAP Staphylococcus aureus ATCC 25923. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

The Rosmary (Rosmarinus officinalis L.) essential oil have antibacterial activity against Staphylococcus aureus. The use of essential oil directly as antibacterial is not practical, so than its made to gel dosage form. The aims of this study to find out physical properties, stability, and antibacterial activity againts Staphylococcus aureus from rosmary leave essential oil gel with variation of consentration carbopol 940 and CMC-Na as gelling agent. The essential oils is isolated with water destilation methode. The rosmary leave gel hand sanitizer is made in five formulas with variation of consentration carbopol 940 and CMC-Na as gelling agent. The gel who made then tested its physical properties, consist of organoleptic, viscocity, pH, spread ability, inherent time, stability, and antibacterial activity with difution methode. The data obtained then analysed with Kolmogorov-Smirnov statistic, then continue to anova one way test and post hoc test with confident level 95 %. The result of this study show that the rosmaryy leave essential oil can be made to gel who and antibacterial activity. The additional of carbopol or CMC-Na as gelling agent may affect the physical properties of gel with increase or decrease the viscosity and inherent ability of gel. The gel with carbopol consentration 0,25% and CMC-Na 0,75% have the best viscosity and inherent ability. The defferent of consentration carbopol and CMC-Na to be affect antibacterial activity againts Staphylococcus aureus. Key Words: Rosmarinus officinalis L., essential oil, hand sanitizer gel, antibacterial, Staphylococcus aureus.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Rosmarinus officinalis L., essential oil, hand sanitizer gel, antibacterial, Staphylococcus aureus.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:37
Last Modified: 01 Oct 2019 03:37
URI: http://repo.setiabudi.ac.id/id/eprint/1552

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