EFEK EKSTRAK ETANOL KULIT BUAH ALPUKAT (Persea americana Mill) TERHADAP KADAR LDL DAN HDL SERUM DARAH TIKUS PUTIH JANTAN HIPERLIPIDEMIA

KLAU, Handrian Skolastika Armince Leki (2015) EFEK EKSTRAK ETANOL KULIT BUAH ALPUKAT (Persea americana Mill) TERHADAP KADAR LDL DAN HDL SERUM DARAH TIKUS PUTIH JANTAN HIPERLIPIDEMIA. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Hyperlipidemia is condition of increasing LDL levels and decrease HDL levels in the blood. This was caused plaque formation on blood vessel walls, causing atherosclerosis which harms human body. Avocado peel is contains flavonoids that act as antioxidants that have ability to ward off free radicals thus preventing LDL oxidation. This study aims was determined effect of avocado peel extract on LDL and HDL levels of blood serum on hyperlipidemia male white rats. This study was used experimental animals male white rats aged 2-3 months with weight 150 to 200 grams. 30 rats were randomly divided into six treatment groups, given to drink boiled water and fed BR II. Except to the normal control, other five treatments groups are given high-fat feeding-induced in the form of lard and quail yolk. Day of 21st, group 4th, 5th and 6th were given ethanol extract of the avocado peel dose of 7 mg/200 grams BW of rat, 14 mg/200 grams BW of rats and 21 mg/200 grams BW of rats. Positive control were given simvastatin dose of 0.18 mg/200 g BW of rats. Negative controls and normal controls were given 0.5% CMC. The LDL and HDL levels were measured with CHOD-PAP method on days of 0, 21st and 35th. Data from measurement of LDL and HDL levels were analyzed using Paired-Samples T Test and Two Way Anova. The results showed extract of avocado peel dose of 7 mg/200 grams BW of rat, 14 mg/200 grams BW of rats and 21 mg/200 grams BW of rats have ability to decrease LDL levels and increase HDL levels. The best effect is shown in dose of 21 mg/200 grams BW of rats. Keywords : hyperlipidemia, LDL, HDL, Persea americana Mill

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	hyperlipidemia, LDL, HDL, Persea americana Mill
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	01 Oct 2019 03:37
Last Modified:	01 Oct 2019 03:37
URI:	http://repo.setiabudi.ac.id/id/eprint/1553

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