UJI AKTIVITAS FRAKSI-FRAKSI DAN EKSTRAK ETANOL BIJI PEPAYA (Carica papaya L.) TERHADAP KADAR KOLESTEROL TOTAL SERUM TIKUS PUTIH JANTAN HIPERKOLESTEROLEMIA

WULANDARI, Rizky (2015) UJI AKTIVITAS FRAKSI-FRAKSI DAN EKSTRAK ETANOL BIJI PEPAYA (Carica papaya L.) TERHADAP KADAR KOLESTEROL TOTAL SERUM TIKUS PUTIH JANTAN HIPERKOLESTEROLEMIA. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Hypercholesterolemia is a risk factor for coronary heart disease that is the leading cause of death in the world. Papaya seeds on previous research contain flavonoids, saponins and tannins that can lower total cholesterol (Hashim 2013). This research was conducted to determine the activity of fractions and ethanol extract of papaya seeds on total cholesterol and determine the effectiveness of the fractions and extract ethanol of papaya seeds on total cholesterol level Papaya seed powder was macerated for 5 days, the results obtained fractionated with a suitable solvent. Research was using test animals were 30 male white rats were made hypercholesterolemia for 2 weeks. Test animals were divided into 6 groups they are CMC 1%, simvastatin, papaya seed extract 30mg/kg BW, n-hexane fraction 11,7mg/kgBW, ethyl acetate fraction 4,7mg/kgBW and fraction water 6,7mg/kgBW, respectively each given for 2 weeks. Total cholesterol measure ments performed on day 28 with CHOD-PAP method. Data cholesterol levels were analyzed by using ANOVA and Tukey test. The results of research showed that the activity of fractions and extract ethanol of papaya seeds can lower total cholesterol levels. Among the fractions and extract ethanol of papaya seeds were the most effective in lowering total cholesterolis a fraction of ethyl acetate 4,7mg/kgBW. Keyword : Carica papaya L., Hypercholesterolime, total cholesterol.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Carica papaya L., Hypercholesterolime, total cholesterol.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 03 Oct 2019 04:29
Last Modified: 03 Oct 2019 04:29
URI: http://repo.setiabudi.ac.id/id/eprint/1592

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