Awombo, Jeniver Rany Chlaudia (2016) FORMULASI DAN UJI MUTU FISIK GEL NATRIUM DIKLOFENAK DENGAN VARIASI KONSENTRASI CARBOPOL 940 SEBAGAI GELLING AGENT. Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.
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Abstract
Diclofenac sodium has anti-inflammatory and analgesic effects, has side effects such as nausea, gastritis, peptic ulcer. To reduce the side effects, the approach performed by making a topical formulation. This research has done by using the Carbopol gel as a gel base because it has non-toxic effect and does not cause hypersensitive reactions. Carbopol 940 can affect the quality of physical gels, for it needs to be examined the effect of Carbopol 940 on the physical quality gels of the diclofenac sodium and the concentration of carbopol 940 that can produce gel of diclofenak sodium with good physical quality. The concentration of Carbopol 940 that used in this research was 1%, 1.5% and 2%. The physical quality of the gel being tested includes an organoleptic test, homogeneity, viscosity, adhesion, dispersive power and pH. The test results were analyzed by using a theoretical approach that compares the test results with the literature and statistical approach using ANOVA at 95% trust level. The results showed variations in the concentration of Carbopol 940 affected the viscosity, the adhesion and the dispersive power of the gel, but did not affect the organoleptic, homogeneity, and pH. More high the concentration of Carbopol was used, then the viscosity and the power of adhesion become more high and great, but it has low dispersive power of the gel because it was inversely proportional to the viscosity. The test results showed that the gel of diclofenac sodium with a 1% and 5% concentration variations of Carbopol 940 have a good physical quality for 4 weeks. The gel formulation with a 2% concentration of Carbopol 940 has a bad dispersive power because it did not reach the range of 5-7 cm. Keywords: gel, diclofenac sodium, carbopol 940, physical quality of the gel.
| Item Type: | Thesis (Karya Tulis Ilmiah) |
|---|---|
| Uncontrolled Keywords: | gel, diclofenac sodium, carbopol 940, physical quality of the gel. |
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi D3 Farmasi |
| Depositing User: | magdalena kartika ningsih |
| Date Deposited: | 10 Oct 2019 04:31 |
| Last Modified: | 10 Oct 2019 04:31 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/1744 |
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