LESTARI, Puji (2014) UJI EFEK ANTIHIPERGLIKEMIK EKSTRAK ETANOLIK KOMBINASI DAUN SALAM (Syzigium polyanthum) DAN DAUN SIRSAK (Anonna muricata) PADA MENCIT JANTAN GALUR SWISS YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Eugenia (Syzigium polyanthum) and soursop leaf (Anonna muricata) are plants which used as antidiabetic drug. This study was aimed to determine effect and most effective dose for combination of ethanol extract of eugenia and soursop leaves in giving decrease effect of blood glucose level in alloxan-induced mice. The study was conducted by using 35 male white mice, swiss, age 3-4 months, weight 20-30 grams. Mice were made diabetic using alloxan intraperitorially. All mice were divided 7 groups, each consisting 5 mice which include group I: negative control, group II: positive control (glibenclamide), group III: eugenia leaf extract (2.62 mg/20 g bw), group IV: soursop leaf extract (3,5 mg/20 g bw), group V combination groups of eugenia and soursop leaf extracts 0,65 mg/20 g bw: 2,625 mg/20 g bw (25%:75%), group VI: 1.31 mg/20 g bw: 1.75 mg/20 g mm (50%:50%) and group VII: 1,96 mg/20 g bw: 0,875 mg/20 g mm (75%:25%). Blood glucose level was observed on 3rd, 7th, and 14th days, measured with glucometer GlucoDr. The results of blood glucose level was analyzed by one way ANOVA (p <0.05), followed by post hoc test. The results showed that adminitration of combination dose of eugenia and soursop leaves in all treatment groups could lower blood glucose level comparable with glibenclamide (p <0.05). Combination dose of eugenia and soursop leaf extracts 1.96 mg/20 g bw: 0,875 mg/20 g bw (75%:25%) gave the most effective lowering effect compared to all treatment groups. Keywords: Syzigium polyanthum., Anonna muricata., Alloxan, blood glucose
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Syzigium polyanthum., Anonna muricata., Alloxan, blood glucose |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Mrs NOVI HANDAYANI |
| Date Deposited: | 10 Oct 2019 08:32 |
| Last Modified: | 10 Oct 2019 08:32 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/1953 |
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