Astuti, Karunita Ika Astuti (2015) AKTIVITAS FRAKSI ETIL ASETAT HERBA MENIRAN MERAH (Phyllanthus urinaria L.) DALAM UJI KEMAMPUAN MEMORI SPASIAL DENGAN METODE RADIAL ARM MAZE DAN HISTOPATOLOGI GIRUS DENTATUS HIPOKAMPUS PADA MENCIT PUTIH JANTAN GALUR BALB/C. Tesis thesis, Universitas Setia Budi Surakarta.
![[img]](http://repo.setiabudi.ac.id/style/images/fileicons/text.png) |
Text
INTISARI.pdf Download (91kB) |
|
Text
2015-SBF 051310057.pdf Restricted to Repository staff only Download (8MB) | Request a copy |
Abstract
Intelligence is an ability to adjust with the environment by blends of attention, concentration and short term memory. Phyllanthus urinary L. is a plant that have active content of flavonoid compound especially quersetin which efficacious in spatial memory activity. The purpose of this study was to determine, effective dose and histopathology of gyrus dentatus in animal test after given ethyl acetate fraction of meniran herb. The research was conducted by administration of ethyl acetate fraction with doses 50 mg/kgBW, 100 mg/kgBW and 150 mg/kgBW for 10 days to white male mice. The research to view error in memory by radial arm maze (RAM) and histopathology of gyrus dentatus. Positive control using quercetin 42 mg/kg BW and negative control using Na-CMC 0.5%. The most effective result at dose 100 mg/kgBW with shows value of 38.619% ± 2.56, the best and smaller value if compared with 50 mg/kgBW and 100 mg/KgBW and negative control, 49.195%±4.27; 53.130%±1.70; and 63.419%±4.55, respectively with positive control value of 32.424%±9.13. Total cell granular gyrus denatatus dose 100 mg/kgBW as 445.8± 2.56, less than positive control as 494.2±3.61 and more than groups with 50 mg/kgBW and 100 mg/kgBW and negative control with total cell 329.8±2.43; 320.8 ± 4.81; and 261.6±2.53, respectively. Keywords: Radial arm maze, ethyl acetate fraction, gyrus dentatus, red meniran (Phyllanthus urinary L).
| Item Type: | Thesis (Tesis) |
|---|---|
| Uncontrolled Keywords: | Radial arm maze, ethyl acetate fraction, gyrus dentatus, red meniran (Phyllanthus urinary L). |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S2 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 06 Nov 2019 07:42 |
| Last Modified: | 06 Nov 2019 07:42 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2078 |
Actions (login required)
 |
View Item |
