Fanany, Aidha Nur (2015) EFEK ANTIHIPERGLIKEMI EKSTRAK ETANOL BIJI MAHONI (Swietenia macrophylla King) DAN EFEKNYA TERHADAP EKSPRESI GLUT2 PADA TIKUS DIINDUKSI STREPTOZOTOSIN-NIKOTINAMID. Tesis thesis, Universitas Setia Budi Surakarta.
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Abstract
Mahogany seed is useful for the treatment of diabetes. This study aims to determine effect of antihyperglycemic, increased expression of GLUT2 in pancreas, and decreased expression of GLUT2 in liver of the mahogany seeds ethanol extract in Streptozotocin-Nicotinamida (STZ-NA) induced rats. This study was divided 5 groups, @ consisting of 5 rats. Group 1 was normal control, 2 was negative control (STZ-NA), 3 was positive control (STZ-NAGlibenklamid 0,5 mg/kg bw), group 4 and 5 were administered with STZ-NA- ethanol extract mahogany seeds 100 mg/kg bw and 200 mg/kg bw. Treatments were administered orally for 14 days. Measured parameters were glucose levels, GLUT2 expression in pancreas and liver. Glucose level data were analyzed with 1Way Anova statistical test, significance (p) <0.05 followed by Tukey HSD. The results showed that group administered with ethanol extract mahogany seeds can lower glucose levels significantly compared to the negative control. Ethanol extract mahogany seeds group 200 mg/kg bw exhibit higher expression of GLUT2 in pancreas than extract group 100 mg/kg bw and negative control. Ethanol extract mahogany seeds 200 mg/kg bw exhibit lower expression of GLUT2 in liver than the dosage of 100 mg/kg bw and negative control. Keywords: Swietenia macrophylla King, antihiperglikemic, pancreas and liver GLUT2 expression, STZ-NA.
| Item Type: | Thesis (Tesis) |
|---|---|
| Uncontrolled Keywords: | Swietenia macrophylla King, antihiperglikemic, pancreas and liver GLUT2 expression, STZ-NA. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S2 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 20 Nov 2019 02:45 |
| Last Modified: | 20 Nov 2019 02:45 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2104 |
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