FORMULASI TABLET EKSTRAK DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb) DENGAN VARIASI KONSENTRASI PVP DAN EXPLOTAB® SECARA GRANULASI BASAH

Prabawanti, Siwi Adityas (2015) FORMULASI TABLET EKSTRAK DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb) DENGAN VARIASI KONSENTRASI PVP DAN EXPLOTAB® SECARA GRANULASI BASAH. Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.

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Abstract

Pandan Wangi leaf (Pandanus amaryllifolius Roxb) contains polyphenols compound which effective to lower blood glucose level. This study was aimed to know whether Pandan Wangi leaves extract could be made tablet dosage form that fulfilled the requirement of tablet physical qualities. Thick extract of pandan wangi leaves was obtained by maceration method with etanol 96%. The tablets were produced using wet granulation method in three formulas : Formula I (PVP 1% and Explotab® 4%), Formula II (PVP 3% and Explotab® 6%), and Formula III (PVP 5% and Explotab® 8%). The obtained tablets were physically tested including weight uniformity, hardness, friability, and disintegration. The obtained data was statistically analyzed using one way Anova continued with SNK test at of 95% confidence by using SPSS 16 program. The result of study showed that extract of Pandan Wangi leaves with binder contents of 1%, 3%, and 5% and disintegration contents of 4%, 6%, and 8% could be made tablet. The three formulas fulfilled the requirement of tablet physical test (weight uniformity, friability, hardness, and disintegration tablet) . Formula I with concentration PVP 1% and Explotab® 4% was the best formula observed from its disintegration and friability compared of Formula II and Formula III. Keywords: Tablet, Pandan Wangi Leaves, PVP, Explotab®, Wet Granulation.

Item Type: Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords: Tablet, Pandan Wangi Leaves, PVP, Explotab®, Wet Granulation.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi D3 Farmasi
Depositing User: magdalena kartika ningsih
Date Deposited: 20 Feb 2020 04:14
Last Modified: 20 Feb 2020 04:14
URI: http://repo.setiabudi.ac.id/id/eprint/2178

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