OPTIMASI TABLET LEPAS LAMBAT IBUPROFEN DENGAN KOMBINASI MATRIKS HPMC K4M DAN Na CMC SECARA SIMPLEX LATICE DESIGN

Sari, Cintia Novita (2013) OPTIMASI TABLET LEPAS LAMBAT IBUPROFEN DENGAN KOMBINASI MATRIKS HPMC K4M DAN Na CMC SECARA SIMPLEX LATICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Ibuprofen is a nonsteroidal anti-inflammatory drugs which often used to relieve pain. Ibuprofen has a short half-life time about 2 hours so patients must often consume, so that it can lead to the risk of forgetting to take medicine. Side effect of ibuprofen is causing gastrointestinal disorders, so that when used repeatedly, it can increase the risk of side effects. Therefore, ibuprofen is a match made in a sustained-release preparation. Based on this, a study was conducted on the manufacture of sustained release ibuprofen tablet using HPMC K4M and Na CMC matrix. This study was based on the simplex lattice design (SLD) method with two matrix components, namely HPMC K4M and Na CMC. The study was made in three formulas i.e. : FI (100% HPMC K4M), FII (50% HPMC K4M : 50% Na CMC), FIII (100% Na CMC). The tablets were made by wet granulation. The formed granules and tablets were tested their physical qualities. The parameters used for SLD equations were flow rate, hardness, dissolution. Then calculated the response of each equation so that the total response was obtained to determine the optimum formula. The results of theoretical and experimental, optimum formula were analyzed using t-test. The results showed that ibuprofen could be made sustained release preparations, and the combination of HPMC K4M and Na CMC matrix. Optimum formula yielded in this study was 60% HPMC K4M : 40% Na CMC. Keywords : Ibuprofen, sustained release, HPMC K4M, Na CMC

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Ibuprofen, sustained release, HPMC K4M, Na CMC
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	13 Feb 2020 03:42
Last Modified:	13 Feb 2020 03:42
URI:	http://repo.setiabudi.ac.id/id/eprint/2223

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