AKTIVITAS KRIM KOMBINASI EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) DAN DAUN BANDOTAN (Ageratum conyzoides L.) DALAM PROSES PENYEMBUHAN LUKA PADA TIKUS HIPERGLIKEMIK

Yasni, Yasni (2014) AKTIVITAS KRIM KOMBINASI EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) DAN DAUN BANDOTAN (Ageratum conyzoides L.) DALAM PROSES PENYEMBUHAN LUKA PADA TIKUS HIPERGLIKEMIK. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Diabetic lesion is one complication of chronic diabetes mellitus constituting open lesion on the skin surface that can be accompanied with local tissue death. Diabetic lesion develops easily into infection due to germ or bacterial entry and the high blood glucose level becomes a strategic place for germ growth. Sirihmerah(Piper crocatum Ruiz & Pav) and bandotan(Ageratum conyzoidesL.) leaves is the natural material that can help accelerate the lesion healing because they contain active antioxidant and antibacterial substances such as volatile oil, flavonoid, saponin, and tannin. The objective of research was to find out the activity of combined sirihmerah and bandotan leaves ethanol extract cream in the process of healing lesion in hyperglycemic rat. This study employed 28 rats divided into 7 groups: group 1 as negative control, group 2 as positive control, group 3 given a single dose of sirihmerah leaves ethanol extract cream, group 4 given a single dose of bandotanleaves ethanol extract cream, groups 5, 6 and 7 given combined sirihmerah and bandotanleaves ethanol extracts cream. The tested animals were acclimatized for 7 days and then undertook initial blood glucose level measurement. Thereafter, they were induced with alloxane 150 mg/kg BW intraperitoneally. The induction was stated as successful when the increase in fasted blood glucose level was beyond 150 mg/dl. The treatment was carried out by applying topically the cream to the wound (lesion) twice a day for 21 days. The observation was conducted by measuring the lesion healing and histopathological test. The result of research, showed that the stocks of of combined sirihmerah and bandotan leavesethanol extracts creamunstable in storage 4 weeks, and based on the changing lesion width and percentage lesion healing, showed that the preparation of combined sirihmerah(15%) and bandotan leaves (5%) ethanol extracts cream had the best lesion healing effect of 97.77%. Keywords: Diabetic lesion healing, Piper crocatum Ruiz & Pav, Ageratum conyzoidesL.

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Diabetic lesion healing, Piper crocatum Ruiz & Pav, Ageratum conyzoidesL.
Subjects:	Q Science > QD Chemistry R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	magdalena kartika ningsih
Date Deposited:	20 Feb 2020 07:25
Last Modified:	20 Feb 2020 07:25
URI:	http://repo.setiabudi.ac.id/id/eprint/2230

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