UJI AKTIVITAS SITOTOKSIK EKSTRAK ETANOL KULIT KAYU MANIS (Cinnamomum burmanni Nees & T.Nees.) Bl) TERHADAP KULTUR SEL KANKER PAYUDARA T47D

HANDAYANI, Maria (2015) UJI AKTIVITAS SITOTOKSIK EKSTRAK ETANOL KULIT KAYU MANIS (Cinnamomum burmanni Nees & T.Nees.) Bl) TERHADAP KULTUR SEL KANKER PAYUDARA T47D. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Breast cancer ranks second in Indonesia from all types of cancer that often affects. Cinnamon can be used as an alternative cancer treatment. The content of cinnamon bark essential oil including, safrole, cinnamaldehyde, eugenol, tannins, flavonoids, saponins. This study aimed to examine the cytotoxic activity of ethanol extract skin cinnamon to inhibit T47D breast cancer cell activity and its IC50. Ethanol extract skin cinnamon was obtained through maceration method by ethanol 96%. The content of flavonoids and cinnamaldehyde was detected by Thin Layer Chromatography (TLC). Cytotoxic test on breast cancer cells T47D used 3-[4,5-dimetilthiazol-2yl]-2,5-difeniltetrazolium bromide (MTT) method and the absorbance was read at ELISA reader. IC50 parameters used are derived from linear regression betwees % viability with log concentration. Doxorubicin is used as a positive control. The result showed that ethanol extract skin cinnamon had cytotoxic effect on breast cancer T47D with IC50 71,157 μg/ml. The ethanol extract skin cinnamon has the potential to be developed as a cemoprefentive agency. Keywords : cinnamon (Cinnamomum burmanni Ness ex. Bl.), doxorubicin, T47D cell lines, cytotoxic, MTT.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	cinnamon (Cinnamomum burmanni Ness ex. Bl.), doxorubicin, T47D cell lines, cytotoxic, MTT
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Mrs NOVI HANDAYANI
Date Deposited:	21 Feb 2020 03:19
Last Modified:	21 Feb 2020 03:19
URI:	http://repo.setiabudi.ac.id/id/eprint/2243

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