OPTIMASI KOMBINASI ASAM STEARAT DAN TRIETANOLAMIN DALAM FORMULA KRIM EKSTRAK DAUN LEGETAN (Spilanthes acmella L.) SEBAGAI ANTIOKSIDAN SECARA SIMPLEX LATTICE DESIGN

Cahyati, Astiti Noer (2014) OPTIMASI KOMBINASI ASAM STEARAT DAN TRIETANOLAMIN DALAM FORMULA KRIM EKSTRAK DAUN LEGETAN (Spilanthes acmella L.) SEBAGAI ANTIOKSIDAN SECARA SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Extract legetan leaf has been shown to have antioxidant activity because it contains flavonoids and polyphenols. The use of extracts legetan leaf directly assessed less well, so that made preparations cream to make it more convenient to use. This study aims to obtain the optimum formula cream extract legetan leaf using additional materials stearic acid and triethanolamine by Simplex Lattice Design method. Extract legetan leaf obtained by maceration using ethanol 96% solvent was then evaporated to obtain a viscous extract. Extract legetan leaf cream made 3 formulas based on the Simplex Lattice Design. Cream the resulting physical properties include organoleptic test, viscosity, viscosity shift, dispersive power, pH, and antioxidant activity. Optimum formulation parameters based on physical properties, namely: viscosity, viscosity shift, dispersive power, using Design Expert software version 8.0.6.1. obtained optimum formula was made and tested physical properties of the cream were analyzed using t-test. IC50 calculation results, the lower the IC50 value of a material, the higher the antioxidant activity. Optimum formula extract cream legetan leaf obtained from composition stearic acid 1,824% and triethanolamine 2,176% with the physical properties of the response of the optimum formula predictions and experimental results showed no significant difference. Cream optimum after two day with 10% extract antioxidant activity of 443,232ppm, and after one month with 10% extract antioxidant activity of 1233,3 ppm. Keywords : optimization, stearic acid, trietanolamine, extract legetan leaf, Simplex Lattice Design, DPPH, antioxidant.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	optimization, stearic acid, trietanolamine, extract legetan leaf, Simplex Lattice Design, DPPH, antioxidant.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	18 Feb 2020 04:03
Last Modified:	18 Feb 2020 04:03
URI:	http://repo.setiabudi.ac.id/id/eprint/2281

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