Yuniasakti, Bunga (2014) UJI AKTIVITAS HIPOGLIKEMIK KOMBINASI EKSTRAK DAUN CEPLIKAN (Ruellia tuberosa L.) DAN GLIBENKLAMID PADA TIKUS PUTIH JANTAN DENGAN INDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Diabetes mellitus is a disease or metabolic disorder characterized with high blood glucose level accompanied with carbohydrate, lipid and protein metabolism disorder as a result of insufficient insulin function. In this study, ceplikan (Ruellia tuberossa L.) leaves contained flavonoid, saponin, and tannin with hypoglycemic activity. This research aimed to find out the hypoglycemic effect of ceplikan leaf extract and glibencamide combination, the effective dose of such combination, and to find out the comparison of hypoglicemic effect between single extract and combination use. The extract of ceplikan leaves was obtained using maceration method with ethanol 70% solvent. The diabetic condition of animal was obtained using monohidrate alloxane induction 100 mg/kg BW. The treatment groups were divided into 6: negative control group with CMC, positive control with glibenclamide (0.09 mg/200 g BW rat), single dose of ceplikan leaves extract (187.5 g rat BW), combination of glibenclamide and ceplikan leaves extract (0.25:0.75; 0.50:0.50; 0.75:0.25). The blood glucose level was measured using glucometer on the day-7, and -14. The result of research showed that the combination of glibenclamide and ceplikan leaves extract had hypoglycemic activity. The effective doses of glibenclamide and ceplikan leaves extract combination were 0.50:0.50; 0.75:0.25. The glibenclamid-extract combination had hypoglycemic effect lower than the single extract did. Keywords: Ruellia tuberossa L., Glibenclamid, monohydrate alloxane, hypoglycemic
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Ruellia tuberossa L., Glibenclamid, monohydrate alloxane, hypoglycemic |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 18 Feb 2020 04:09 |
| Last Modified: | 18 Feb 2020 04:09 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2289 |
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