UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEM EKSTRAK ETIL ASETAT KULIT BATANG MUNDU (Garcinia dulcis Kurz) SECARA in vitro

Sari, Dany Putri Artika (2014) UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEM EKSTRAK ETIL ASETAT KULIT BATANG MUNDU (Garcinia dulcis Kurz) SECARA in vitro. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Malaria is an infectious disease caused by the parasite plasmodium which is transmitted through the bite of infected Anopheles mosquitoes. This is still a major problem in health sector, especially in the tropical regions. Garcinia dulcis Kurz is a plant that has one as antimalarial activity . This study aims to determine the potention of inhibition test antimalarial through haem polymerization of ethyl acetate extract from the stem bark of Garcinia dulcis Kurz. Extracts were made by multilevel maceration using n-hexane and ethyl acetate solvent. Haem polymerization inhibitory activity ethyl acetate extract from the stem bark of Garcinia dulcis Kurz carried out by the method of Bassilico methods. Chloroquine used a positive control, DMSO as a solvent control, and negative control used aquades. Absorbance of β-hematin formation in vitro at acidic pH was measured using an ELISA reader at a wavelength of 405 nm. Inhibiting of haem polymerization activity stated by IC50 value. IC50 value is determined by probit analysis. The results showed that the ethyl acetate extract of the stem bark Garcinia dulcis Kurz has inhibitory activity of haem polymerization with IC50 value is 0.248 ± 0.060 mg / ml. Keywords: Garcinia dulcis Kurz, antimalarial, haem polymerization inhibitory activity, IC50

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Garcinia dulcis Kurz, antimalarial, haem polymerization inhibitory activity, IC50
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	18 Feb 2020 04:12
Last Modified:	18 Feb 2020 04:12
URI:	http://repo.setiabudi.ac.id/id/eprint/2294

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