Mandasari, Devi (2014) AKTIVITAS ANTI-INFLAMASI EKSTRAK ETANOL 96% BIJI WALUH (Cucurbita moschata D.) PADA TIKUS PUTIH JANTAN YANG DI INDUKSI KARAGENAN. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Inflammation is the protective attempt by organism to remove adverse stimulation and to initiate tissue healing process. This research aimed to find out the anti-inflammatory effect and varian doses of gourd seed ethanol 96% extract in the caragenan-induced white male rats. The anti-inflammatory effect testing was conducted on 30 rats with artificial edema method in the sole of rat induced with caragenan 2%. The tested animal were divided into 5 groups, i.e. CMC-Na 0,5%, 150 mg/Kg BW, 300 mg/Kg BW, 600 mg/Kg BW, and Na-dichlophenac. The measurement was conducted one hour after caragenan 2% injection on rat sole intraplantarly. The result was measured for 5 hours and calculated for AUC and percentage of antiinflammatory activity. The result showed that ethanol 96% extract of gourd seed could give antiinflammatory effect. The gourd seed extract at doses 300 mg/kg BW and 600 mg/kg BW had percentage of anti-inflammatory equal to Na-dichlophenac at dose 4.5 mg/kg BW. The phenolic compounds contained in gourd seed (Curcubita moschata D.) extract were flavonoid, saponin, steroid and terpenoid which expected could give anti-inflammatory effect. Keywords: Na-dichlophenac, gourd seed ethanol extract, anti-inflammation
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Na-dichlophenac, gourd seed ethanol extract, anti-inflammation |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 18 Feb 2020 04:18 |
| Last Modified: | 18 Feb 2020 04:18 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2302 |
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