Lerebulan, Exaudian Flourens (2015) AKTIVITAS KOMBINASI EKSTRAK ETANOLIK BATANG BROTOWALI (Tinospora crispa (L) Miers) DAN FRAKSI ETANOLIK DAUN KEPEL (Stelechocarpus burahol (BI) Hook. F. & Th) TERHADAP NEKROSIS DAN JUMLAH SEL β PANKREAS TIKUS YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.
![[img]](http://repo.setiabudi.ac.id/style/images/fileicons/text.png) |
Text
Abstrak.pdf Download (817kB) |
|
Text
BAB II.pdf Restricted to Repository staff only Download (339kB) | Request a copy |
|
Text
BAB III.pdf Restricted to Repository staff only Download (326kB) | Request a copy |
|
Text
BAB IV.pdf Restricted to Repository staff only Download (317kB) | Request a copy |
|
Text
BAB V.pdf Download (2MB) |
|
Text
COVER - BAB I.pdf Download (438kB) |
Abstract
Brotowali stem (Tinospora crispa (L) Miers) commonly used to treat diabetes mellitus. Kepel leaves (Stelechocarpus burahol (BI) Hook. F. & Th) are known to have antioxidant activity. This study aims to determine the inhibitory activity and an increase in mean diameter of the islets of Langerhans and the percentage of necrosis and normal pancreatic β-cell count of ethanolic extract of stem brotowali and ethanolic fractions of kepel leaves or a combination there of in alloxan-induced diabetic rats. Diabetic animals were conducted by induction of alloxan dose 125 mg/ kg bw. The conditions of diabetic in test animals induced with alloxan dose 125 mg / kg bw. The treatment group were divided into 8 groups: normal control, negative control of 0.5% CMC-Na, positive control of glibenclamide (0.09 mg/200 g BW), ethanolic extract of brotowali stem (100 mg/200 g BW), fraction ethanolic of Kepel leaf (18 mg/200 g BW), ethanolic extract combination dose of stem brotowali - ethanolic fraction of Kepel leaves (75 mg/200 g BW: 4.5 mg/200 g BW, 50 mg/200 g BW: 9 mg / 200 g BW, 25 mg/200 g BW: 13.5 mg/200 g BW). Given treatment for 14 days and on 15th day test animals were sacrificed and histological preparations made his pancreas. The data obtained were analyzed with the Kolmogorov-Smirnov test (p> 0.05), followed One Way ANOVA (P <0.05) and Duncan Post Hoc Test. The results showed that a dose ethanolic extract of brotowali stem of 100 mg/200 g BW and dose combination of 75 mg/200 g BW rat: 4.5 mg/200 g BW is a single dose and dose combinations are best, in terms of percentage of the lowest nekrosisnya, an increase in mean diameter of the islets of Langerhans and count of β-cell normal. Key word: etanolic extract, etanolic fraction, brotowali stems, kepel leaf, pancreas necrosis
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | etanolic extract, etanolic fraction, brotowali stems, kepel leaf, pancreas necrosis |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 18 Feb 2020 06:39 |
| Last Modified: | 18 Feb 2020 06:39 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2342 |
Actions (login required)
 |
View Item |
