UJI AKTIVITAS FRAKSI ETIL ASETAT EKSTRAK ETANOL UMBI SARANG SEMUT (Myrmecodia tuberosa (non Jack)) : EVALUASI TERHADAP PROLIFERASI LIMFOSIT DAN SEL T47D SERTA SEL VERO YANG DIINDUKSI DOKSORUBISIN

Battista Leki, Karol Giovani (2015) UJI AKTIVITAS FRAKSI ETIL ASETAT EKSTRAK ETANOL UMBI SARANG SEMUT (Myrmecodia tuberosa (non Jack)) : EVALUASI TERHADAP PROLIFERASI LIMFOSIT DAN SEL T47D SERTA SEL VERO YANG DIINDUKSI DOKSORUBISIN. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Doxorubicin is a chemotherapy agent that can inhibit the growth of T47D cells but is cytotoxic to Vero cells and inhibit lymphocyte proliferation. The use of doxorubicin combination with other agents may increase the effects and reduce side effects. The use of doxorubicin can be combined with herbal therapy. One of herbal therapies used to fight cancer is Myrmecodia tuberosa. This study aimed to examine the cytotoxic effects Myrmecodia tuberosa against T47D and lymphocyte proliferation as well as the effect of the combination ofMyrmecodia tuberosaand doxorubicin against T47D cells and Vero cells. The method used in this research is the MTT assay. This method is based on the change of tetrazolium salt into formazan in active mitochondria in viable cells. Test analysis performed by one-way ANOVA post hoc Tukey test and the Bonferroni test. The results showed ethyl acetate fraction of ethanol extract of Myrmecodia tuberosa (FEE) are cytotoxic against T47D cells and increase proliferation of lymphocytes. In the combination test, the FEE increase the cytotoxic effects of doxorubicin on T47D cells, the FEE also reduce the cytotoxic effects of doxorubicin on Vero cells. Keywords: Doxorubicin, Myrmecodia tuberosa, T47D cell, Vero cell, Lymphocytes.

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Doxorubicin, Myrmecodia tuberosa, T47D cell, Vero cell, Lymphocytes.
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	magdalena kartika ningsih
Date Deposited:	21 Feb 2020 01:20
Last Modified:	21 Feb 2020 01:20
URI:	http://repo.setiabudi.ac.id/id/eprint/2350

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