PENGEMBANGAN FORMULA FAST DISINTEGRATING TABLET DOMPERIDON DALAM KOMPLEKS INKLUSI β-SIKLODEKSTRIN DENGAN SUPER DISINTEGRANTS CROSPOVIDONE,FILLER BINDER AVICEL PH102, DAN PEMANIS SORBITOL

Lailiyah, Munifatul (2015) PENGEMBANGAN FORMULA FAST DISINTEGRATING TABLET DOMPERIDON DALAM KOMPLEKS INKLUSI β-SIKLODEKSTRIN DENGAN SUPER DISINTEGRANTS CROSPOVIDONE,FILLER BINDER AVICEL PH102, DAN PEMANIS SORBITOL. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Domperidone is anantagonist dopamine-2 receptor that has been used as antiemetic. Formulation of domperidone in fast disintegrating tablet using inclusion complex with β-cyclodextrin is an appropriate alternative to enhance the palatability and disintegrate rapidly in the mouth. This research aimed to optimize and evaluate the influence of crospovidone, Avicel PH 102 and sorbitol on disintegration time, friability, hardness, palatability and drug release of domperidone fast disintegration tabletusing inclusion complex with βsiklodekstrin. Simplex lattice design method was applied to optimize fast disintegrating tablet of domperidone in inclusion complex with β-cyclodextrin. Crospovidone, Avicel PH102 and sorbitol were used as independent variable. The optimum area was determined using superimposed contour plot of combination of disintegration time, wetting time, friability, hardness, the amount of drug released at 1 minute and dissolution efficiency using Design Expert software. The results showed that crospovidone as superdisintegrant affected on reducing disintegration time, wetting time and drug release. Enhancement of Avicel PH 102 aid the wicking process thus reduced the disintegration time if combined with crospovidone. Enhancement of sorbitol concentration increased the mouth feel and hardness, and reduced the friability. Interaction between Avicel PH102 and sorbitol, crospovidone and sorbitol, and interaction of three variables reduced the wetting time, disintegration time, and friability, moreover increased the hardness and drug release. The optimum area of domperidone in βcyclodextrin inclusion complex fast disintegration tablet was in range 4 – 6.4 mg of crospovidone, Avicel PH102 42 – 52 mg and sorbitol 80 – 94 mg. Key words: crospovidone, Avicel PH102, sorbitol, fast disintegrating tablet using inclusion complex with β-cyclodextrin

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	crospovidone, Avicel PH102, sorbitol, fast disintegrating tablet using inclusion complex with β-cyclodextrin
Subjects:	Q Science > QD Chemistry R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	magdalena kartika ningsih
Date Deposited:	26 Sep 2019 08:17
Last Modified:	26 Sep 2019 08:17
URI:	http://repo.setiabudi.ac.id/id/eprint/2356

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