PEMBUATAN KRISTAL SFERIS FISETIN DENGAN METODE SPHERICAL AGGLOMERATION PELARUT ASETON

Setyaningrum, Lisa (2018) PEMBUATAN KRISTAL SFERIS FISETIN DENGAN METODE SPHERICAL AGGLOMERATION PELARUT ASETON. Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.

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Abstract

Fisetin (3.3 ', 4', 7-tetrahydroxyflavone), is a polyphenolic compound with various activities as a natural antioxidant and anti-inflammatory. Fisetin has a low solubility in water solvents. So the provision of fisetin in oral dosage form is very limited. The purpose of this research is to know fisetin can be made spherical crystals by spherical agglomeration method and the effect of increasing solubility to the resulting spherical crystals. The process of crystallization of spherical fisetin by way of selection of formula to polymer PEG 4000 1%, 1% PVP and 1% PVA. Then added the solution of fisetin and chloroform. Selected formulas that produced spherical crystals were further tested including microscope morphology tests, SEM tests, determination of crystal yield percentage and solubility test. The results showed that fisetin can be made spherical crystals by spherical agglomeration method. The selected polymer is PEG 4000 with 1% concentration, 600 rpm stirring speed with a stirring time of 1 hour. Resulting crystal size of 50 μm, crystal yield of 96.5% and solubility of fisetin spherical crystalline (8.8446 mg / ml). Keyword : Fisetin, Spherical crystalization, Spherical agglomeration, PEG 40

Item Type:	Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords:	Fisetin, Spherical crystalization, Spherical agglomeration, PEG 40
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi D3 Farmasi
Depositing User:	B Supri Yadi
Date Deposited:	20 Feb 2020 03:23
Last Modified:	20 Feb 2020 03:23
URI:	http://repo.setiabudi.ac.id/id/eprint/2452

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