AKTIVITAS ANTIARTRITIS KOMBINASI EKSTRAK ETANOL RIMPANG JAHE MERAH (Zingiber officinale Rosc.) DAN TANAMAN ANTING-ANTING (Acalypha indica Linn.) TERHADAP TIKUS YANG DIINDUKSI COMPLETE FREUND’S ADJUVANT

Puspitasari, Ismi (2014) AKTIVITAS ANTIARTRITIS KOMBINASI EKSTRAK ETANOL RIMPANG JAHE MERAH (Zingiber officinale Rosc.) DAN TANAMAN ANTING-ANTING (Acalypha indica Linn.) TERHADAP TIKUS YANG DIINDUKSI COMPLETE FREUND’S ADJUVANT. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Arthritis is a disease affecting the musculoskeletal system. Rheumatoid arthritis is a type of arthritis that is caused by an autoimmune reaction.The purpose of this study was to determine the antiarthtritis activity of combination on red ginger rhizome and acalypha plant ethanolic extracts. This study used five groups of rats and induced complete Freund's adjuvant on plantar foot. Each group was given treatment. Group 1 was given a red ginger rhizome single extract 56 mg/200g BB rats, group 2 was given a acalypha plant single extract 200 mg/kg, group 3 was given a combination on red ginger rhizome and acalypha plant extracts, group 4 was given of triamcinolone 0,072 mg/200g BB rats, and group 5 was given CMC 1% . Test material is administered orally, and edema volume measurements using plethysmometer. The results showed that a acalypha plant single extract have the ability to reduce both the volume of the edema. While triamcinolone provide improved histopathology profile joints through improved joint space distance and the absence of cell infiltration. While the combination of red ginger rhizome and acalypha plant extracts have the ability to reduce leukocyte counts. However, based on statistical analysis, there were no significant differences between the groups of red ginger rhizome single extract, acalypha plant single extract and a combination of red ginger rhizome and acalypha extracts against a positive control triamcinolone. Thus, the combination of red ginger rhizome and acalypha plant extracts have antiartritis activity comparable with single dosage of each of these plants. Keywords : red ginger rhizome, acalypha plant, complete Freund's adjuvant, antiarthritis, triamcinolone.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	red ginger rhizome, acalypha plant, complete Freund's adjuvant, antiarthritis, triamcinolone.
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	19 Feb 2020 07:06
Last Modified:	19 Feb 2020 07:06
URI:	http://repo.setiabudi.ac.id/id/eprint/2523

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