Ayu, Luchas Is (2014) UJI AKTIVITAS KOMBINASI EKSTRAK ETANOLIK BUAH BUNCIS (Phaseolous vulgaris L.) DAN METFORMIN SEBAGAI ANTIHIPERGLIKEMIK PADA MENCIT JANTAN Balb/C YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.
![[img]](http://repo.setiabudi.ac.id/style/images/fileicons/text.png) |
Text
BAB II.pdf Restricted to Repository staff only Download (491kB) | Request a copy |
|
Text
BAB III.pdf Restricted to Repository staff only Download (306kB) | Request a copy |
|
Text
BAB IV.pdf Restricted to Repository staff only Download (207kB) | Request a copy |
|
Text
BAB V-LAMPIRAN.pdf Download (2MB) |
|
Text
COVER-BAB I.pdf Download (802kB) |
|
Text
INTISARI.pdf Download (90kB) |
Abstract
Diabetes mellitus (DM) is a disease characterized with the increased blood glucose above normal due to insulin deficiency produced by pancreatic gland within the body. Stringbean (Phaseolus vulgaris L) presumably contains flavonoid constituting anti-diabetic compound. Metformin is an oral anti-diabetic agent that can lower the blood glucose level. This study aimed to find out the effect of stringbean (Phaseolus vulgaris L.) fruit ethanol extract and metformin combination administration on the Balb/C male mice induced with alloxan to be hyperglycemic. The mice were divided into six treatment groups, each of which consisted of 5 mice. The first group was given cmc 0.5% as negative control, the second was given metformin 1.3 mg/20 g BW, the third stringbean extract at dose 42 mg/20 g BW mice, the fourth, fifth and sixth were given the combination of stringbean fruit extract and metformin at doses 31.5 mg: 0.325 mg (75%: 25%), 21 mg : 0.65 mg (50% : 50%) , and 10.5 mg : 0.975mg (25% : 75% ). All of groups were induced with alloxane on the day-0 (after fasted for 16 hours) intraperitoneally. The examination of blood sugar level was conducted on the day3, -6, and -9. The result of statistic analysis on string fruit and metformin extract combination showed a significant difference, so that the combination of stringbean fruit extract at dose 31.5 mg: metformin 0.325 mg (75%:25%) was the most effective one in lowering the blood glucose level in Balb/C white male mice that were made hyperglycemic with alloxane induction. Keywords: anti-diabetic, anti-hyperglycemic, stringbean fruit extract, alloxane, mice.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | anti-diabetic, anti-hyperglycemic, stringbean fruit extract, alloxane, mice. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 19 Feb 2020 07:16 |
| Last Modified: | 19 Feb 2020 07:16 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2533 |
Actions (login required)
 |
View Item |
