FORMULASI DAN UJI STABILITAS FISIK SUSPENSI ASAM MEFENAMAT DENGAN SUSPENDING AGENT NATRIUM KABOKSILMETILSELULOSA (Na-CMC)

Lilo, Sherly Clariesta (2018) FORMULASI DAN UJI STABILITAS FISIK SUSPENSI ASAM MEFENAMAT DENGAN SUSPENDING AGENT NATRIUM KABOKSILMETILSELULOSA (Na-CMC). Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.

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Abstract

Mefenamic acid is the anti-inflammatory drugs nonsteroidal activity that has anti-inflammatory, analgesic, antipyretic and antirematik with having practically no solubility soluble in water. This study was aimed to find out how was the influence of suspending agent Na-CMC on the physical properties of Mefenamid Acid, as well as to find out what concentration that could provide the most excellent physical stability among four formulas. Mefenamic acid suspension was made preparations in four different formulations. The different of the formulations was on the concentrations of NaCMC from formula 1, 2, 3 and 4 are (0,25%); (0,5%); (0,75%); dan (1%). Suspension which has been created then done physical quality testing includes of: organoleptis, pH, viscosity, easily whether or not the cast, volume of sedimentation and redispersibility. The results of testing each formula in the analysis using One Way Anova test followed Post Hoc Turkey Tests 95% confidence levels ton find out the best suspension formula and stable during storage. The results showed that the variation of the suspending agent affected on physical quality test suspension. Formulation 3 based on the test results of the physical quality of the suspension has the best stability of four suspension formula made with concentrations of suspending agent Sodium Karboksimetil Cellulose (Na-CMC) is 0.75%. Keyword: Suspension, Mefenamic acid, Suspending agent, Na-CMC

Item Type: Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords: Suspension, Mefenamic acid, Suspending agent, Na-CMC
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi D3 Farmasi
Depositing User: B Supri Yadi
Date Deposited: 20 Feb 2020 03:25
Last Modified: 20 Feb 2020 03:25
URI: http://repo.setiabudi.ac.id/id/eprint/2543

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