FORMULASI DAN EVALUASI ORALLY DISINTEGRATING TABLET (ODT) FAMOTIDIN VARIASI SUPERDISINTEGRANT STARCH 1500 DAN CROSPOVIDONE DENGAN METODE KEMPA LANGSUNG

Susilowati, Siti (2018) FORMULASI DAN EVALUASI ORALLY DISINTEGRATING TABLET (ODT) FAMOTIDIN VARIASI SUPERDISINTEGRANT STARCH 1500 DAN CROSPOVIDONE DENGAN METODE KEMPA LANGSUNG. Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.

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Abstract

Famotidine is used as a duodenal and gastric ulcers, making it suitable for Orally Disintegrating Tablets (ODT) preparations. ODT has characteristics that quickly dissociate in the oral cavity. The objective of this study was to investigate is that famotidine can be made ODT preparations, the effect of superdisintegrant starch 1500 and crospovidone on the physical quality of preparations, and concentration of superdisintegrant starch 1500 and crospovidone to obtain famotidine ODT with rapid destruction time. This study formulated ODT famotidine with a superdisintegrant starch 1500 7%, combination of superdisintegrant starch 1500 and crospovidone 3%: 4%, and using a superdisintegrant crospovidone 7 %. Preparation of famotidine ODT using direct induced method. Tests conducted to determine the physical quality of famotidine ODT are uniformity of weight, size, hardness, brittleness, wetting time, crushed time, diversity of content, taste test, crushed test time in vivo and then analyzed using statistical test SPSS Statistics version 23. The results showed that famotidine can be made ODT preparations, superdisintegrant starch 1500 and crospovidone have an effect on the physical quality of preparations, and combination of superdisintegrant starch 1500 and crospovidone 3%: 4% resulted in rapid destruction time of 34.30 seconds Kata kunci : Orally Disintegrating Tablet, Famotidine, Starch 1500 dan Crospovidone

Item Type: Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords: Orally Disintegrating Tablet, Famotidine, Starch 1500 dan Crospovidone
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi D3 Farmasi
Depositing User: B Supri Yadi
Date Deposited: 20 Feb 2020 03:26
Last Modified: 20 Feb 2020 03:26
URI: http://repo.setiabudi.ac.id/id/eprint/2556

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