ANTI-ARTRITIS DAN ANTI-INFLAMASI HERBA ANTING-ANTING (Acalypha indica L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR

KOLOBANI, MATIAS NATANIEL (2014) ANTI-ARTRITIS DAN ANTI-INFLAMASI HERBA ANTING-ANTING (Acalypha indica L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Acalypha indica L. has been use as anti-arthritic and anti-inflammatory medicine. The study aims to determine anti-arthritic and anti-inflammatory activity as well as chemical compounds to responsible again anti-inflammatory activity from Acalypha indica L. whole plant. The research was conducted by completely randomized method. In anti-arthritic test, test animal were devided to six groups by five rats in every group. Group 1: normal controle; group 2: negative controle; group 3 : triamcinolone; group 4-6 : Acalypha indica ethanol extract (AIEE) 50, 100, 200 mg/kg bw, respectively. Test animals induced with 0.2 ml of CFA and observed that it looked edema and erythema is a symptom of arthritis, then treated and observed a decrease in volume of edema and histopathological profile. In anti-inflammatory test, test animal were devided to eight groups by six rats in every group. Group 1: normal controle; group 2: negative controle; group 3: diclofenac sodium; group 4 and 5: (AIEE) 100, 200 mg/kg bw, respectively; group 6 – 8: fraksi II, IV, and V 100 mg/kg bw, respectively. Test animals were treated with the test sample, then the animals test induced by carrageenan 1 hour later. Observed decrease in edema volume every hour for 6 hours. The result of anti-arthritic activity tes showed that Acalypha indica L. ethanol extract dose 200 mg/kg bw provided edema volume decrease and histopathological profile comparable with triamcinolone (p <0.05). Anti-inflammatory test showed that the fraction II provides anti-inflammatory effects comparable with Na. Diclofenac (p <0.05). Chemical compounds responsible for the anti-inflammatory activity was triterpenoids, steroids and polyphenols. Keywords : Acalypha indica L., anti-arthritic, anti-inflammatory, triterpenoids, steroids, polyphenols.

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Acalypha indica L., anti-arthritic, anti-inflammatory, triterpenoids, steroids, polyphenols.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	magdalena kartika ningsih
Date Deposited:	21 Feb 2020 02:59
Last Modified:	21 Feb 2020 02:59
URI:	http://repo.setiabudi.ac.id/id/eprint/2575

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