PENGARUH PEMBERIAN EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana L.) TERHADAP ENZIM ALP (Alkali phospatase) PADA TIKUS PUTIH YANG DIINDUKSI RIFAMPISIN DAN ISONIAZID

Djawa, Novita Rambu Ana (2014) PENGARUH PEMBERIAN EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana L.) TERHADAP ENZIM ALP (Alkali phospatase) PADA TIKUS PUTIH YANG DIINDUKSI RIFAMPISIN DAN ISONIAZID. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Mangosteen is a medicinal plant that contains polyphenols, flavonoids, saponins, and xanton. Garcinone E, α-mangostin, γ-mangostin and mangiferin is xanton class of compounds that have antioxidant activity. Rifampicin and isoniazid cause hepatotoxicity in the liver. This study aimed to determine the effects of mangosteen peel extract to the effects of decreased levels of the enzyme ALP in the Wistar rat strain induced rifampicin and isoniazid. The extraction methodusedwasmaceratedusingethanolsolvent. ALPenzymeassayperformedwith5 groups, each groupinducedrifampicinandisoniazid. Group Iwas treatedmangosteenpeel extract(450 mg/kgBW) orally, groupIIwas treatedmangosteenpeel extract(900 mg/kgBW) orally, Group IIIwas treatedmangosteenpeel extract(1080 mg/ kg BW) orally, Group IV,positive controlgivenmethicol®(63 mg/kgBW), andgroupV, a negative controlwas given1% CMC. Parameters usedto decreased levels ofALPenzymemeasuredfromday 0andday 28. Determination ofALPenzyme levelswere measuredonday 0andday 28. The results obtainedwere analyzed byOne WayANOVAtestfollowed byTukeyHSDtest. The results showedthatof thehistogramandthe averagedifferencedecreased levels ofALPenzymethateffectivelyreduce levels ofALPenzymeisa groupof mangosteenpeel extract900mg/kg body weight(387.90). Based on thestatistical testANOVAwithTukeyHSDtestgroupmangosteenpeel extractefefktiflower levels ofthe enzymeALPis900mg/kgBW (P <0.05). Keywords: mangosteen , rifampicin, isoniazid, ALP

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	mangosteen , rifampicin, isoniazid, ALP
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	19 Feb 2020 07:50
Last Modified:	19 Feb 2020 07:50
URI:	http://repo.setiabudi.ac.id/id/eprint/2658

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