DISOLUSI TERBANDING TABLET NIFEDIPIN MEREK DAGANG DAN GENERIK YANG BEREDAR DI PASARAN

Sari, Nur Indah (2014) DISOLUSI TERBANDING TABLET NIFEDIPIN MEREK DAGANG DAN GENERIK YANG BEREDAR DI PASARAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Nifedipin is used in the medicinal treatment of hypertension. There’re two kinds of nifedipine have been marketed, branded products and generic products, both of them have difference in formulation and fabrication. Nifedipine is included in drug class II according to the Biopharmaceutical Classification System (BCS), so it is necessary to do comparative dissolution test to ensure similarity of the quality products. This study was aimed to know and compare the physical quality and the similarity of dissolution profile (f2) between branded and generic products of nifedipine. This study was used 5 tablets of nifedipine consist of two kinds of generic products and three kinds of branded products. Dissolution tests was conducted according to the British Pharmacoeia, used dissolution tester type 2 (paddle method), the speed of rotation is 50 rpm, in 900 mL HCl 0,1 N medium at 37 ± 0,5ºC. Determination of nifedipine tablets dissolution used a UV-Vis spectrophotometer in 238 nm. Parameter were observated are Q45 value, DE60, and the similarity factor (f2). Based on the results of physical quality and dissolution profiles, nifedipine tablets of branded and generic products comply the requirements of good tablets in quality control, while the value of similarity factor (f2) for all of the products showed good equivalence, in range 50-100. Keywords : Nifedipine, Dissolution, BCS II, Similarity factor (f2).

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Nifedipine, Dissolution, BCS II, Similarity factor (f2).
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	19 Feb 2020 07:50
Last Modified:	19 Feb 2020 07:50
URI:	http://repo.setiabudi.ac.id/id/eprint/2660

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