KAJIAN KOMBINASI EKSTRAK ETANOL 70% DAUN YAKON (Smallanthus sonchifolius) DAN ACARBOSE TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT YANG DIINDUKSI ALOKSAN

Rahmadhani, Rizkasari (2014) KAJIAN KOMBINASI EKSTRAK ETANOL 70% DAUN YAKON (Smallanthus sonchifolius) DAN ACARBOSE TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Leaves yakon (Smallanthus sonchifolius) is a medicinal plant useful as antidiabetic. Yakon leaves contain flavonoids that act as antioxidants and have αglucosidase inhibiting activity. Acarbose is an antidiabetic drug that inhibits the activity of enzymes α-glucosidase in order to keep blood sugar low. This research aims to determine the effect of a combination of 70% ethanol extract of the leaves yakon-acarbose to decrease blood glucose levels of male mice Balb/C hyperglycemia. Method of determination of blood glucose levels used is alloxan diabetes test. Test animals were divided into 6 groups, each group consisted of 5 animals. Group I control diabetes CMC 0.5%, group II control synthetic insulin, group III acarbose, group IV 70% ethanol extract of the leaves yakon, group V combination of 70% ethanol extract of the leaves yakon-acarbose (100%:100%), group VI combination of 70% ethanol extract of the leaves yakon-acarbose (50%:50%). Provision of test solutions conducted over 14 days after induction of alloxan and measurements were performed on days 7 and 14, then performed a statistical test with one way analysis of variance with a level of 95% and then continued Post Hoc Test. The results showed that 70% ethanol extract of the leaves yakon give effect to a decrease in blood glucose levels when compared with the same synthetic insulin and combination of 70% ethanol extract of the leaves yakonacarbose (50%: 50%) more effective in lowering blood glucose levels than the single dosage. Keywords: Smallanthus sonchifolius, acarbose, alloxan, blood glucose

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Smallanthus sonchifolius, acarbose, alloxan, blood glucose
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	20 Feb 2020 02:25
Last Modified:	20 Feb 2020 02:25
URI:	http://repo.setiabudi.ac.id/id/eprint/2756

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