Sawal, Rizky Ardian Hartanto (2014) PENGARUH EKSTRAK ETANOL DAN FRAKSI n-HEKSANA BUAH TAKOKAK (Solanum torvum Sw.) TERHADAP RESPON IMUN SELULER PADA MENCIT PUTIH JANTAN Balb/c DENGAN UJI DELAYED-TYPE HYPERSENSITIVITY (DTH). Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Takokak fruit contains steroid and flavonoid are expected to have ability in modulate immune system. The purpose of this study is to know and prove ethanol extract and n-hexane fraction effect toward cellular immune response with mice right footpad thickness change. This research is use 45 mice and divided into 9 group which is negative control (CMC 0,5%), stimuno, methylprednisolon, ethanol extract of fruit takokak 75, 150, and 400 mg/kg BW, and n-hexane fraction of fruit takokak 20, 40, and 80 mg/kg BW. Each of mice were sensitize with SRBC 20% 0,1 mL i.p. then were given treatment for 7 days. On 6th day, the thickness of mice right footpad was measured then injected with SRBC 0,1% 0,02 mL s.c. The thickness of mice right footpad was again measured after 24 hours to know DTH response. The data were analyzed with one-way ANOVA. The result showed that ethanol extract of takokak fruit with doses 150 and 300 mg/kg BW can increase DTH response 55,41 ± 2,5790 and 57,51 ± 3,6908respectively. n-Hexane fraction of fruit takokak with doses 20, 40, and 80 mg/kg BB can suppress DTH response respectively 30,42 ± 4,7043, 30,03 ± 5,0101 and 25,72 ± 6,1311. Keywords:n-Hexane fraction, takokak fruit, SRBC, steroid,delayed typehypersensitivity.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | n-Hexane fraction, takokak fruit, SRBC, steroid,delayed typehypersensitivity. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 20 Feb 2020 02:27 |
| Last Modified: | 20 Feb 2020 02:27 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2777 |
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