UJI EFEKTIVITAS SUSU SAPI DAN KAMBING PROBIOTIK TERHADAP PENURUNAN KADAR MALONDIALDEHID (MDA) PADA HATI MENCIT YANG TERPAPAR FORMALIN

Fanany, Aidha Nur (2013) UJI EFEKTIVITAS SUSU SAPI DAN KAMBING PROBIOTIK TERHADAP PENURUNAN KADAR MALONDIALDEHID (MDA) PADA HATI MENCIT YANG TERPAPAR FORMALIN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Excessive or long-term consumption of formalin may cause oxidative stress and cell death. Cow's and goat's probiotic milk are containing lactic acid bakterium (BAL), which could increase the antioxidants SOD and antimicrobial compounds. MDA (malondialdehyde) is an indicator of oxidative damage to cell membranes. This study aims to determine the effect of cow's and goat’s probiotic milk to decrease MDA levels in the livers of mice exposed to 50 ppm formalin dose and the type of probiotic milk effective . This study uses the normal control and the formalin control, as well as group therapy cow’s probiotic milk consisting of 108 CFU/ ml, goat’s probiotic milk 108 CFU/ml , cow's milk, and goat’s milk. Each treatment group were given orally formalin and then treated milk. This study used 5 mice per group for 14 days. MDA levels (nmol/g) was measured with a spectrophotometer UV-Vis wavelength of 532 nm. Results were analyzed by ANOVA followed by post hoc test level of 95 % . Results show that all test groups affect the decreasing of MDA levels (nmol/g). Average levels of MDA per group 0.97; 5.36; 2.26; 1.36; 2.93 and 1.87. Goat’s probiotic milk is more effective than other treatment groups. The presence of protein and BAL in milk can affect the damage prevention or inhibition of mice liver cell that are exposed to excessive doses of formalin. Key words: Cow's milk, goat’s milk probiotic, malondialdehyde, liver.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Cow's milk, goat’s milk probiotic, malondialdehyde, liver.
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	magdalena kartika ningsih
Date Deposited:	21 Feb 2020 03:35
Last Modified:	21 Feb 2020 03:35
URI:	http://repo.setiabudi.ac.id/id/eprint/2810

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