OPTIMASI TABLET LEPAS LAMBAT IBUPROFEN DENGAN MATRIKS HPMC DAN MC SECARA SIMPLEX LATTICE DESIGN

Wardani, Arum Triyas (2012) OPTIMASI TABLET LEPAS LAMBAT IBUPROFEN DENGAN MATRIKS HPMC DAN MC SECARA SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Ibuprofen is nonsteroidal antiinflamatory drugs that is often used to relieve pain. Ibuprofen has a shorthalf lifetime about 2 hours so patients must often consume so that it can lead to the risk of forgetting to take medicine. Side effects of ibuprofen is causing gastrointestinal disorders, so that when used repeatedly can increase the risk of side effects. Therefore, Ibuprofen is suitable made in sustained release. Based on this, this study was done manufacture of sustained release ibuprofen tablet using HPMC and MC matrix. This study was based on the method simplex lattice design (SLD) with two matrix components, that was HPMC and MC. The research was made in three formulas are: FI(100% HPMC), FII(50% HPMC: 50% MC), FIII(100% MC). The tablets were made by wet granulation. The obtained granules and tablets were tested the physical quality. The parameters used for SLD equation was flowability, compactibility, dissolution. Then calculated the response of each equation so that the total response was obtained to determine the optimum formula. The results of theoretical and experimental optimum formula were analyzed using t-test. The results showed that ibuprofen sustained release preparations could be made, and the combination of HPMC and MC matrix affected the physical quality and the release of ibuprofen tablet. The proportion that produced sustained release ibuprofen tablet with a maximum physical quality was the formula containing 30% HPMC: 70% MC. Keywords : Ibuprofen, sustained release, HPMC, MC

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Ibuprofen, sustained release, HPMC, MC
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	B Supri Yadi
Date Deposited:	20 Feb 2020 04:34
Last Modified:	20 Feb 2020 04:34
URI:	http://repo.setiabudi.ac.id/id/eprint/2818

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