EFEK DIURETIK FRAKSI AIR DARI EKSTRAK ETANOL 95% AKAR ALANG-ALANG (Imperata cylindrica var major) PADA TIKUS PUTIH JANTAN GALUR WISTAR

Santoso, Edy (2012) EFEK DIURETIK FRAKSI AIR DARI EKSTRAK ETANOL 95% AKAR ALANG-ALANG (Imperata cylindrica var major) PADA TIKUS PUTIH JANTAN GALUR WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

One of the plants that are empirically efficacious diuretic is root imperata (Imperata cylindrica). Herbal diuretic is expected to be more secure than synthetic diuretics. The main function of diuretics is to mobilize edema fluid, which means changing the balance of fluid in such a way that the extracellular fluid volume returned to normal. Aimed of this study to determined the diuretic effect of fraksi water of alang-alang leaves on Wistar male rats. Rott imperata (Imperata cylindrica) leaf powder were extracted by maceration with faction of water solvent. Faction of water was tested in animal test to determine the diuretics effect compared with manitol (20%). Diuretic test was conducted using diuretics method, ie imposing any material with a dose of 2.5 ml/200 g BW. This method uses 25 animals Wistar male rats were divided into 5 groups: group I (negative control), group II (positive control), group III, IV, V, animals test were given by air, manitol 20%, faction of water suspension dose of 0,8; 1,7; 3,4 mg / 200g BW respectivelly. Animals test in the metabolic cage, is measured urine volume in hours-2, 4, 6, 8 and 12. Diuretic effect is obtained by calculating the cumulative urine volume and AUC (Area Under the Curve). The data obtained were analyzed by one way ANOVA with a level of 95% significant, then test by LSD (Least Significant Difference). The results showed that AUC 0-2 and AUC 6-12 value, positive control and fraksi water of root imperata leaves dose 1,7 and 3,4 mg / 200g body weight there were significant differences (p <0.05) with negative controls (mean on the hour to 06, have demonstrated a diuretic effect). The result of AUC 6-8 and AUC 8-12, indicates that the positive control and extract dose of 1,7 mg / 200g body weight was significantly different (p <0.05) with a negative control. This means, a second dose manitol and have diuretic effects. Keywords: root imperata leaf, fraksi water, diuretic

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	root imperata leaf, fraksi water, diuretic
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	B Supri Yadi
Date Deposited:	20 Feb 2020 04:41
Last Modified:	20 Feb 2020 04:41
URI:	http://repo.setiabudi.ac.id/id/eprint/2834

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