Yanti, Susi (2014) PENGARUH PEMBERIAN KOMBINASI EKSTRAK KULIT KAYU MANIS (Cinnamomum burmanni Nees ex Bl.) DAN EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP KADAR LDL DAN HDL TIKUS PUTIH JANTAN. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Increased levels of high desinty lipoprotein (HDL) and decreased levels of low density lipoprotein (LDL) in the blood is a risk factor for atherosclerosis leading to coronary heart disease (CHD). Bark of cinnamon (Cinnamomum burmanni Nees ex Bl.) and leaf of papaya (Carica papaya L.) contain flavonoids, saponins, and tannins. Flavonoids and saponins can reduce blood cholesterol levels, and prevented the oxidation of cholesterol in the body. The purpose of this research is to find out combination effect cinnamon’s bark extract and papaya’s leaf extract on increase of HDL and decrease of LDL levels serun in tested animals. The research was used 35 animals test and the mice were devided into 7 groups. There were negative control (CMC 0,5%), positve control (simvastatin), extract bark cinnamon 75 mg/Kg BW, extract leaf papaya 750 mg/Kg BW, combination I (57mg/Kg BW:188mg/Kg BW), combination II (38mg/Kg BW:375mg/Kg BW), and the combination of III (19mg/Kg BW:563mg/Kg BW). Animals test of LDL and HDL level were measured on day 0, day 14, day 21, day 28. Concluded this research that the combination of extract bark cinnamon and extract leaf papaya affects on Increased HDL and decreased LDL levels in the animals’ blood. The most effective combination dose is dose combination III 19mg/Kg Bw:563mg/Kg BW. Dose combination III has the same activity with a extract papaya and simvastatin. Keywords: LDL, HDL, kulit kayu manis (Cinnamomum burmanni Nees ex Bl.) bark of cinnamon (Cinnamomum burmanni Nees ex Bl.) and leaf of papaya (Carica papaya L.).
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | LDL, HDL, kulit kayu manis (Cinnamomum burmanni Nees ex Bl.) bark of cinnamon (Cinnamomum burmanni Nees ex Bl.) and leaf of papaya (Carica papaya L.). |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 20 Feb 2020 02:37 |
| Last Modified: | 20 Feb 2020 02:37 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2835 |
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